Pathophysiology Of Migraine Headache

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Migraine it is the most commonest type among the primary headache. It is one form of vascular headache. Vascular headache are throbbing and pulsating pain caused by the activation of nerve fibres that lies within the brain blood vessel walls which passes within the meninges. Which result in decrease in blood flow and oxygen to the brain and increase blood flow of other blood vessels. Migraine headaches are the repeated attacks of moderate to severe pain that is throbbing or pulsating pain which mainly affects one side of the head lasting from 4- 72 hours if untreated.(1)

EPIDEMIOLOGY According to the present scenario there are approximately 28 million migraine sufferers aged above 15 years in the United States. Among the 28 million the male female ratio is 1:3 i.e. 21 million of females and 7
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Fluctuating estrogen levels are a potent migraine trigger. Many women have onset of migraine at menarche, severe attacks during menstruation (menstrual migraine), and worsening during menopause. Oral contraceptives and other hormone therapy occasionally trigger or worsen migraine and have been associated with stroke in women who migraine with

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