Epilepsy is one of the most prevalent neurological disorder around the world1. It has been estimated that 5.8 per 1,000 population in developed countries and about 12.8 per 1000 in lower income countries suffer from this disorder2. Pharmacotherapy is the primary method for controlling epileptic seizure. However, about 30% of patients suffer from refractory epilepsy or are unable to tolerate adverse effects of antiepileptic drugs 3, 4. Thus, it is of great importance to find new drugs with increased safety and efficacy profile.
The exact pathophysiology of epileptic seizure needs to be fully elucidated, though imbalance between the excitatory and inhibitory neurotransmission in the central nervous system (CNS) may play important roles in this
The exact pathophysiology of epileptic seizure needs to be fully elucidated, though imbalance between the excitatory and inhibitory neurotransmission in the central nervous system (CNS) may play important roles in this