Parvovirus

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Parvovirus is a SS DNA virus, as stated in question it’s genome is either + or – strand. Their genome is linear, non segmented, and single- stranded DNA of about 5 KB. Most of the strand packaged into virions are – strand, but some parvoviruses package equal amounts of (+) and (-) strand. Parvovirus can’t become latent, since they are ssDNA and will be destroyed. All parvoviruses require receptor-mediated endocytosis for cell infection. Their host is Mammals including humans, parvovirus has all genes that are useful for structural protein virus relies on cells for everything else. Parvovirus is either densoviruses or dependoviruses. Autonomous parvovirus is liner single-stranded and of negative strand virus. In order to replicate from the infected cell, cell must be in a dormant state. …show more content…
Genome is relatively long and single stranded coding region is bracketed by short palindromic terminal sequences capable of folding into hair pin duplex. The parvovirus replication begins with attachment and genome enters in a host cell, replication occurs in the nucleus. Their DNA must be a replicon. Parvovirus replicate their DNA through a sequence of duplex. For replication 3’ end serves as a primer due to the looping hairpin structure, helicase opens up 5’ end for polymerase activity. Concatermeric genomes are formed by unidirectional, quasi-circular rolling mechanism. VP3 latches on to DNA for encapsidation. Parvoviruses integrate into cellular DNA at high frequency to establish a stable latent state, they will infect cells that replicate quickly. Finally, the assembled capsid promotes the replication shift from synthesizing duplex DNA to single negative sense strand, which will be packed in with virion and will be released upon lysis of

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