Parkinson Disease: An Essay On The Shaking Palsy

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irst described by James Parkinson in his classic 1817 monograph, "An Essay on the Shaking Palsy" [1], Parkinson disease (PD; also known as paralysis agitans) is a progressive neurodegenerative disease that affects between 100 and 200 per 100,000 people over 40, and over 1 million people in North America alone [2,3]. Parkinson disease is uncommon in people younger than 40, and the incidence of the disease increases rapidly over 60 years, with a mean age at diagnosis of

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