Abstract
Paclitaxel is the most effective anticancer agent. It is utilized for various cancer types, especially for the treatment of ovarian cancer. However, paclitaxel resistance is one of the foremost problem for cancer chemotherapy. Most importantly, emergence of paclitaxel resistance due to mutation (F270V) in β-tubulin has been extremely deliberated in recent years. With the rise of paclitaxel resistant mutation in β-tubulin there is a need to add a novel inhibitor from natural source, as they have less chance of getting resistance additionally less side effects. Keeping this in mind we have utilized experimental and insilco approaches to isolate the potent inhibitor for β-tubulin target protein. Firstly, phytocompounds from Cassia fistula
Paclitaxel is the most effective anticancer agent. It is utilized for various cancer types, especially for the treatment of ovarian cancer. However, paclitaxel resistance is one of the foremost problem for cancer chemotherapy. Most importantly, emergence of paclitaxel resistance due to mutation (F270V) in β-tubulin has been extremely deliberated in recent years. With the rise of paclitaxel resistant mutation in β-tubulin there is a need to add a novel inhibitor from natural source, as they have less chance of getting resistance additionally less side effects. Keeping this in mind we have utilized experimental and insilco approaches to isolate the potent inhibitor for β-tubulin target protein. Firstly, phytocompounds from Cassia fistula