PCL 304: Assignment On The Principles Of Acidic Activity

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NAME UKAH R.C
MATRIC NUMBER NSC/2014/887
COURSE CODE PCL 304
ASSIGNMENT :
QUESTION NUMBER 1:
LIST THE PRINCIPLES OF CHEMOTHERAPEAUTIC RESISTANCE
Introduction:
PRINCIPLE : Principle is an essential factors or elements that may have impact on the survival mechanism, which may either be from environment or the person taking the drugs or factor participating may engineer drug resistance.
RESISTANCE: It is reduction in drug's effectiveness in which the drug may be fake , adulterated or substandard .Resistance is also the ability of microbes to resist toxic effects of drugs growth.
It is commonly believed that therapy resistance is the result of a selection during therapy
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In addition, their large structures limit penetration into cerebrospinal fluid, urine, and eyes. In plasma, echinocandins have a high affinity to serum proteins. Echinocandins do not have primary interactions with CYP450 or P-glycoprotein pumps. Caspofungin has triphasic nonlinear pharmacokinetics, while micafungin (hepatically metabolized by arylsulfatase, catechol O-methyltransferase, and hydroxylation) and anidulafungin (degraded spontaneously in the system and excreted mostly as a metabolite in the urine) have linear elimination. Younger patients exhibit a faster rate of elimination of micafungin and …show more content…
THEY ARE AS FOLLOW
1. Attachment of the virus to the cell surface: This can be blocked by Enfuvirtide e.g in HIV
2. Uptake into intracellular vesicles (endosomes). Blocked by Enfuvirtide e.g in HIV
3. Uncoating of virus:- Can be blocked by Amantadine e.g in Influenza A
4. Integration of the viral DNA into chromosomal DNA of the host cell: Can be blocked by Fomivisen e.g in Cytomegaloviruv.
5.Template production and RNA or DNA replication (Nucleic acid synthesis) . This Can be blocked by purine,pyrimidine analogs and reverse transcriptase inhibitors.
6. mRNA transcription , processing and translation of mRNA to protein : blocked by Methisazone e.g in Variola
7. Post-translational modification of proteins:
8. Assembly of the components into the whole virus: it's blocked by Methisazone e.g in Variola
9.Exit from the cells.:can be inhibited by Neuramidase inhibitors e.g in

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