Synthesis of oleyl 9,(12)-hydroxy-10,(13)-oleioxyoctadecanoate (OLHYOODT) (4)
The reaction mixture was heated on a magnetic heater and stirrer until it reached the experiment temperature; catalyst sulfuric acid (SA) and desiccant of silica gel (SG) were added to the mixture at that moment to remove the water during the reaction. The reaction temperatures were held constant within a range of ±1°C. A mixture of HYOODA 3 (5 g; 0.01 mol), oleyl alcohol (OL) (10 g; 0.02 mol) in a 250-mL three-neck flask equipped with a cooler, dropping funnel and thermometer was heated for 1 h at 90 °C. During the 1 h reaction SG was put in the oven at 180 °C for drying. After 1 h SG drying the SG (50% of the HYOODA) and SA (3.5 g: 0.007 mol) were added to the mixture.
The reaction mixture was heated on a magnetic heater and stirrer until it reached the experiment temperature; catalyst sulfuric acid (SA) and desiccant of silica gel (SG) were added to the mixture at that moment to remove the water during the reaction. The reaction temperatures were held constant within a range of ±1°C. A mixture of HYOODA 3 (5 g; 0.01 mol), oleyl alcohol (OL) (10 g; 0.02 mol) in a 250-mL three-neck flask equipped with a cooler, dropping funnel and thermometer was heated for 1 h at 90 °C. During the 1 h reaction SG was put in the oven at 180 °C for drying. After 1 h SG drying the SG (50% of the HYOODA) and SA (3.5 g: 0.007 mol) were added to the mixture.