The diagnosis of esophageal CD can be suspected if dysphagia or odynophagia is present, but these are not specific for CD. In patients with CD known to exist in other gastrointestinal segments, the right diagnosis should be suggested but needs confirmation by means of endoscopy and tissue examination. In most cases, endoscopic findings alone are not specific; histological changes, more likely than not, fail to show granulomas and can only be considered compatible with CD. Yet with the exclusion of other specific diagnoses, and in the proper clinical setting, the diagnosis reasonably can be made with these tests.
