Methods
Modeling cancer progression employing a mixed number linear program. The problem of partitioning change events into a temporal sequence of events was developed in as Associate in Nursing number Linear Program (ILP), within which Associate in nursing optimumpartition should satisfy 2 biologically significant needs. The first, termed exclusivity of mutations, derives from the common assumption that at the most one driver mutation takes place throughout every step (or phase) of cancer progression. The second establishes progression across phases by imposing that, for any given patient, a mutation in some cistron should happen in a very given progression introduce order for one more cistron to become mutated in a very ensuant part. The
Modeling cancer progression employing a mixed number linear program. The problem of partitioning change events into a temporal sequence of events was developed in as Associate in Nursing number Linear Program (ILP), within which Associate in nursing optimumpartition should satisfy 2 biologically significant needs. The first, termed exclusivity of mutations, derives from the common assumption that at the most one driver mutation takes place throughout every step (or phase) of cancer progression. The second establishes progression across phases by imposing that, for any given patient, a mutation in some cistron should happen in a very given progression introduce order for one more cistron to become mutated in a very ensuant part. The