Neutrophils are a part of the innate immune system which provides a quick responders to the site of injury and inflammation. When there is an injury to mast cells, they release chemical messengers such as histamine and cytokines. Histamine signals vascular permeability and vasodilation, which allows leakage of blood components intended to fight infection and initiate healing. Cytokines are nonspecific chemical messengers which alert uninjured cells that an injury has occurred. Chemokines are small cytokines which are have the ability to move in a specific direction towards a higher concentration of chemokines, this process is called chemotactic. In the healthy adult neutrophils circulate in a dormant state, the cells must be primed or activation
