Neuroofibromatosis Type 1 Research Papers

Neurofibromatosis Type 1 is the most frequent autosomal dominant neurogenesis disorder in the United States known today. Considering that school problems are the single most common complication of NF1 that effects the patients’ everyday learning environment entirely (Tonsgard 1, School Problems), neurofibromatosis is a severe genetic disorder that cannot be cured. Neurofibromatosis patients tend to obtain learning disabilities and developmental abnormalities due to brain tumors, attention deficits, and cognitive impairments. Neurofibromatosis is a neurological disease that is caused by a mutation on the gene that codes for a protein called neurofibromin. Neurofibromin maintains the job of the protein called “ras” in regulation. Ras ensures the regulation of cell division, so when a mutation occurs, the cells do not know when to stop dividing, thus causing tumors. These tumors grow underneath the skin, on the nerves, and in the brain (“Neurofibromatosis Type 1”). There are three different types of this disease, NF1, NF2, and the rarest form, Schwannomatosis. In cases of NF1, a person …show more content…
Some of most common symptoms include café au lait spots (dark spots on the skin), neurofibromins on the skin, bone defects, scoliosis, lisch nodules in the eye, high blood pressure, and most importantly, learning disabilities and developmental abnormalities (“Neurofibromatosis Type 1”). Scientists have concluded that the symptoms themselves vary along with severity and occurrence. “Scientists don’t know exactly why symptoms vary so much, even among people from the same family. But they predict that genetics has to do a lot with it. It is likely that each patient’s unique genetic makeup influences the severity of his or her symptoms” (“Neurofibromatosis Type 1”). Some very common and frequent symptoms that relate to learning and developmental problems include brain tumors, attention deficits, and sensory and cognitive