Amyloid Cascade Hypothesis By Karl Herrup: Article Analysis

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Neurocognitive disorders are shown to be some of the most prominent disorders in the US. Neurocognitive disorders can effect any demographic; they do not choose only certain type of people, and they can have an effect on anyone no matter their age, gender, ethnicity, etc. A Neurocognitive disorder is a disorder that is usually developed over time and affects mainly people of the older generation. A lot of these neurocognitive disorders are shown as a deterioration of certain areas in the brain. Some diseases that are branches within the neurocognitive disorder are Alzheimer’s disease, Parkinson’s disease, and Dementia. Studying neurocognitive disorders is a big topic to study in modern science and there is always something new to be researched …show more content…
Herrup attempts to disprove the hypothesis and looks forward to other possible hypothesis. After looking pointed towards animal studies, it was seen that animals can have large amyloidal burdens in their brains but still do not have any signs of dementia (Herrup, 2015). This shows that although the hypothesis could show that there are cases where people have the large burden and have Alzheimer’s disease, it is also possible that a person with the disease does not need to have the amyloid deposition. Amyloid deposition is not seen all around through the cases of Alzheimer’s disease. Believers of the hypothesis are still researching how patients with the deposition cannot have Alzheimer’s disease. Mice were given the mutated amyloid precursor protein and the result of that was that there were some small memory differences but there were no symptoms of Alzheimer’s disease like neurofibrillary tangles or synaptic loss (Herrup, 2015). This explanation could show that although the amyloid precursor protein could be associated with memory, but it is not connected to Alzheimer’s disease in a way that it kills the

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