Nuclear Factor Kappa B as A Prognostic Factor in Nephrotic Syndrome and acute kidney injury
Abstract:
Background: Nephrotic syndromes and acute kidney injury (AKI) are very common diseases. Nuclear Factor (NF)-кB is a protein complex controlling the transcription of DNA. NF-кB is activated in tubules and glomeruli in various experimental models. Several studies have suggested that detection of NF-кB could be considered as a sign of renal injury.
Objectives: This study aims to determine the association between NF-кB level and renal disease progression among patients with AKI and nephrotic syndrome.
Methods: A comparative follow up study was conducted to assess in situ expression of NF- B in renal biopsy of nephrotic syndrome and AKI patients. Kidney samples were obtained by percutaneous renal biopsy. The renal biopsies from 20 patients with nephrotic range proteinuria were studied and compared with 10 patients with AKI. The diagnosis of glomerulonephritis and AKI was made based on clinical and histological findings. …show more content…
Among nephrotic patients; the mean ± SD NF-кB level was the highest among those with membranoproliferative glomerulonephritis (MPGN) (795 ±643.5), followed by the mesangioproliferative glomerulonephritis (MesPGN) (598.7 ± 166.5) while lowest level was found in patients with membranous nephropathy (387.5 ± 101.1). There was a significant correlation between NF-кB level and serum creatinine level among the whole patients before treatment (r=0.531, P= 0.003) and after three months follow up (r=0.568, P= 0.001). Among each study group; we couldn’t elicit a significant positive correlation with proteinuria except in the FSGS group(r=0.67, P=
Abstract:
Background: Nephrotic syndromes and acute kidney injury (AKI) are very common diseases. Nuclear Factor (NF)-кB is a protein complex controlling the transcription of DNA. NF-кB is activated in tubules and glomeruli in various experimental models. Several studies have suggested that detection of NF-кB could be considered as a sign of renal injury.
Objectives: This study aims to determine the association between NF-кB level and renal disease progression among patients with AKI and nephrotic syndrome.
Methods: A comparative follow up study was conducted to assess in situ expression of NF- B in renal biopsy of nephrotic syndrome and AKI patients. Kidney samples were obtained by percutaneous renal biopsy. The renal biopsies from 20 patients with nephrotic range proteinuria were studied and compared with 10 patients with AKI. The diagnosis of glomerulonephritis and AKI was made based on clinical and histological findings. …show more content…
Among nephrotic patients; the mean ± SD NF-кB level was the highest among those with membranoproliferative glomerulonephritis (MPGN) (795 ±643.5), followed by the mesangioproliferative glomerulonephritis (MesPGN) (598.7 ± 166.5) while lowest level was found in patients with membranous nephropathy (387.5 ± 101.1). There was a significant correlation between NF-кB level and serum creatinine level among the whole patients before treatment (r=0.531, P= 0.003) and after three months follow up (r=0.568, P= 0.001). Among each study group; we couldn’t elicit a significant positive correlation with proteinuria except in the FSGS group(r=0.67, P=