Nephroblastoma Essay

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Introduction Primary renal tumors account for approximately 2% of all canine cancers.11 Tissues of origin include the renal epithelium, renal mesenchyme or embryonal tissue of mixed origin.1 Roughly 10% of primary renal tumors originate from embryonal pluripotential blastema, which include Wilms’ tumor, nephroblastoma, and embryonal nephroma.11 The majority of diagnosed renal tumors occur in older dogs; however, nephroblastoma is unique in that it is seen in juveniles. The mean age for diagnosis of nephroblastoma is 5.2 years, but they have been diagnosed in dogs as young as 1 year and as old as 12 years.1 Nephroblastomas are usually malignant but can be benign.8 They are most commonly unilateral and have a lower metastatic rate than other primary renal …show more content…
Gasser AM, Bush WW, et al. Extradural Spinal, Bone Marrow, and Renal Nephroblastoma. Journal of the American Animal Hospital Association. 2003; 39: 80-85.
4. Jubb, Kennedy, Palmer. Pathology of Domestic Animals. 5th ed. Elsevier Ltd; 2007. Urinary system, Renal Neoplasia; pp. 498-503.
5. Michael HT, Sharkey LC, et al. Vet Med Today: Pathology in Practice. JAVMA 2013; Vol. 242, No. 4.
6. Montinaro V, Boston SE, Stevens B. Renal nephroblastoma in a 3-month-old golden retriever. Canadian Veterinary Journal. 2013; 54: 683-686.
7. Ramani P, Cowell J: The Expression Pattern of Wilms’ Tumour Gene (WT1) Product in Normal Tissues and Paediatric Renal Tumors. Journal of Pathology. 1996; Vol.179: 162-168.
8. Seaman R, Patton C: Treatment of Renal Nephroblastoma in an Adult Dog. J Am Anim Hosp Assoc 2003;39:76-79.
9. Sivacolundhu R, Withrow S. Neoplasia of the Urinary Tract. In: Monnet E. Small Animal Soft Tissue Surgery. 1st ed. Danvers, MA: Wiley-Blackwell, 2013;573-576.
10. Traslavina RP, Aleman M, et al. Vet Med Today: Pathology in Practice. JAVMA 2013; Vol 242, No 12.
11. Withrow SJ, Vail DM. Small Animal Clinical Oncology. 5th ed. St Louis, Missouri: Saunders Elsevier; 2013. Tumors of the urinary system; p

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