Biological parameters were evaluated for the early diagnosis of neonatal sepsis . The most useful are enumeration of white blood cells (WBC ), total number of neutrophils (TN), the immature relative to the total neutrophils (I / T) and C-reactive protein (CRP) . [ 4-7] However, despite the number of available tests, none of them is absolutely reliable for early and accurate diagnosis .
Several cytokines, such as IL -1B , IL-6 , IL- 8 and TNF -a are important mediators in the systemic host response to infection. the high peripheral blood (PB) , the levels of these cytokines have been found useful in the diagnosis of early as well as late onset neonatal sepsis . However, there is less known about the value of cytokine levels in cord blood (CB …show more content…
reported an increase in levels of IL-6 in the CB newborns (32- 42 wk gestation) who developed an infection, and Shimoya al.found and a high level of IL -8 to CB in preterm fetuses (22-26 weeks gestational age) with chorioamnionitis.
More recent studies have also found that IL-6 and IL-8 CB levels could be useful for identifying infected infants. [13,14]
The diagnosis of neonatal sepsis is one of the most difficult tasks in clinical medicine. [2] A number of independent observers suggested that several different determination laboratories are individually useful for detecting bacterial infection in newborns . thereof include the serum immunoglobulin M, neutrophils and bands represent , serum C -reactive protein orosomucoid ( alpha-acid glycoprotein ) , serum haptoglobin , serum fibrinogen , erythrocyte sedimentation rate , smears buffy - coat and immature neutrophil / total. [ 3-17 ]
Bacteria isolated from the blood is the most specific and standard method used to diagnose neonatal sepsis . Positive cultures varied between 8 % and 73% in the diagnosis of neonatal sepsis potential . [23] An additional drawback of culture based diagnosis is the testing time of 24 to 48
Several cytokines, such as IL -1B , IL-6 , IL- 8 and TNF -a are important mediators in the systemic host response to infection. the high peripheral blood (PB) , the levels of these cytokines have been found useful in the diagnosis of early as well as late onset neonatal sepsis . However, there is less known about the value of cytokine levels in cord blood (CB …show more content…
reported an increase in levels of IL-6 in the CB newborns (32- 42 wk gestation) who developed an infection, and Shimoya al.found and a high level of IL -8 to CB in preterm fetuses (22-26 weeks gestational age) with chorioamnionitis.
More recent studies have also found that IL-6 and IL-8 CB levels could be useful for identifying infected infants. [13,14]
The diagnosis of neonatal sepsis is one of the most difficult tasks in clinical medicine. [2] A number of independent observers suggested that several different determination laboratories are individually useful for detecting bacterial infection in newborns . thereof include the serum immunoglobulin M, neutrophils and bands represent , serum C -reactive protein orosomucoid ( alpha-acid glycoprotein ) , serum haptoglobin , serum fibrinogen , erythrocyte sedimentation rate , smears buffy - coat and immature neutrophil / total. [ 3-17 ]
Bacteria isolated from the blood is the most specific and standard method used to diagnose neonatal sepsis . Positive cultures varied between 8 % and 73% in the diagnosis of neonatal sepsis potential . [23] An additional drawback of culture based diagnosis is the testing time of 24 to 48