Examples Of Negative Feedback

Improved Essays
Negative feedback is an important physiological regulation and control. Body water volume is a regulated variable. Disproportion of water volume in the body (too high or too low), require the action of hormone. In case of abnormal loss of body fluids, ADH will help to maintain body fluids by reducing the elimination of urine. ADH impact is example of negative feedback effect, where physiological regulation is maintained.
Maintained body
Water volume > excessive loos

+> hypothalamus +> ADH

Negative feedback
Key:
>leads to
+> stimulates
Reference:
SK277 (2004) The endocrine system, in Control and Comunication,The Open University, Milton Keynes ii.) Negative feedback and regulation
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The onset of syndrome can be triggered by prolonged use of medication such corticosteroids used for treatment of arthritis. Also, Cushing’s syndrome can be caused by tumor of pituitary or adrenal glands. The treatment would require the surgical intervention, the removal of tumor and possible long-termed use of medications in order to sustain normal function of removed glands. iii.) Positive feedback increases variable and boosting physiological processes.
Figure 1 A flow diagram showing the positive feedback of the oxytocine hormone in controlling uterine muscle contraction during labour. The number steps are explained in the text. (1) Oxytocin is transported to the blood stream after he was secretes from hypothalamic nuclei the capillary network of posterior lobe of pituitary. The strech receptors of birth canal send the action potential (2) to the hypothalamus (3) via spinal cord. Hypothalamus stimul;ates further production of oxytocin (4) which is transported to the posterior ppituitary gland (5) and released into the capilary network again. The regulation of oxytocin in the blood last until child is born. When contractions stops, also the action potential is no more activated by strech receptors in cervix.
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The level of TSH dropping rapidly from the onset of treatment to 0.30 arbitrary unitsml-1 in week 2. Decrease of TSH continues to his lowest point of 0.05 arbitrary unit ml-1 in week 8 and after it remain low and steady. In contrast, hormone levels rise week by week with one or two slight drop. T3 is reaching his peak in week 9, 1.75 ng ml-1 wherebout T4 is 1.10 µg ml-1 in week 13.The level of both hormones steadily decline after their peak and seems that they remain stable.
Negative feedback effect register the decreased level of thyroid hormones in the blood, therefore it increases the releasing of TSH to stimulate thyroid glans to release T3 (tri-iodothyronine) and T4 (thyroxin) hormones. iii.) It appears that the reason for hypothyroidism in this case is long lasting inadequate level of iodine in the diet. Where is no iodine , there is no secretion of thyroid hormones.
d.)

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