Exosomes have several characteristics which make them favorable candidates for epigenetic messengers. These characteristics include their ability to change cell physiology, selectivity, and their ability to have their own contents changed as a result of environmental stressors. It has been shown that embryonic stem cell derived exosomes can reprogram hematopoietic progenitors; in other words, they can induce these differentiated hematopoietic stem cells back into pluripotency through their molecular cargo.11 Furthermore, multiple studies have confirmed the selectivity of EVs and have confirmed that there are most likely multiple different routes by which they may seek out and deposit their contents into target cells; often through complementary surface proteins or through similar mechanisms as those in antigen-presenting cells.12 Lastly, the ability for the contents of exosomes to be altered based on environmental stressors has been proved through the work of Ferrante et al.,13 explained
Exosomes have several characteristics which make them favorable candidates for epigenetic messengers. These characteristics include their ability to change cell physiology, selectivity, and their ability to have their own contents changed as a result of environmental stressors. It has been shown that embryonic stem cell derived exosomes can reprogram hematopoietic progenitors; in other words, they can induce these differentiated hematopoietic stem cells back into pluripotency through their molecular cargo.11 Furthermore, multiple studies have confirmed the selectivity of EVs and have confirmed that there are most likely multiple different routes by which they may seek out and deposit their contents into target cells; often through complementary surface proteins or through similar mechanisms as those in antigen-presenting cells.12 Lastly, the ability for the contents of exosomes to be altered based on environmental stressors has been proved through the work of Ferrante et al.,13 explained