NSCLC Screening Recommendation

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NSCLC screening microdevice
Lung cancer has one of the highest incidence and mortality rates among all cancers worldwide. Many cases of lung cancer remain asymptomatic until the disease progresses to an advanced non-curable stage. Currently there are very few early detection techniques. Imaging tests such as CT scans, MRIs, and chest x-rays done on patients in response to other conditions, such as pneumonia or heart disease, can by accident detect lung cancers early in their asymptomatic form. These patients sometimes can respond well to treatment and may even be completely cured of lung cancer. ("Can non-small cell lung cancer be found early?")
Lung cancers are classified either as a non-small cell lung carcinoma (NSCLC) or as a small cell
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It will aid in the early detection of one of the most common and deadly forms of lung cancer NSCLC. Alk is a type one glycoprotein resides on cell membranes and normally only expressed in the nervous system. The ALK protein resides on chromosome 2p23. Studies show a prevalence of ALK gene rearrangements in lung cancer affecting over 40,000 patients worldwide each year and is considered a key oncogenic driver in NSCLC. Over 50% of patients presenting with ALK gene rearrangement and advanced or metastatic NSCLC showed a positive response rate to Pfizer’s medication Xalkori. A screening test that can identify these specific patients would help doctors develop their treatment plan in a more efficient manner. ("VENTANA ALK Scoring Interpretation Guide for non-small cell lung carcinoma (NSCLC)", …show more content…
The sample is injected into the microfluidic chip using a pneumatic pump at a prescribed and optimized pressure. After the sample is processed the collected tumor cells are rinsed repeatedly and gently to remove any unbound cells and cellular material. The CTC is then stained directly stained on the collection grid using a DAB IHC detection kit. The staining which can be done with minimal training can be completed in about 2 hours. Scoring the screening test positive or negative can be done in one of two ways. Lab personnel after minimal training would be able to secure the result by simply looking for the indicative red brown color on the tumor collected tumor cells. A second option would be to have the slide scanned and photographed with a commercialized slide scanner. The scanner itself could be programmed with the applicable scoring algorithm enabling it to score the slide, archive the slide scans, and easily send the scan to another physician if a consult is needed. The scan could also become part of the patient’s electronic health record. Commercial examples of currently available slide scanners able to be programmed as described are the Aperio Slide Scan or the Ventana iScan Coreo. The scanners themselves may currently be cost prohibitive, but as with most electronic devices their process should make them more affordable for the small labs in the very near future. Until that

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