Some mechanisms of myocardial damage, such as necrosis and apoptosis, initiate during the period of ischemia and worsen during the first minutes of reperfusion. Other mechanisms of myocardial injury and vascular damage occur only in the first minutes of reperfusion. The overall result of IRI is represented by necrosis and apoptosis, as well as a transient reduction of contractility of surviving myocardium, that is the myocardial stunning. This is in part due to the presence of non-necrotic tissue no longer able to contract, or contracting with less force. Stunning can last from minutes to days, in relation to the severity of the preceding ischemia and in relation to the severity of reperfusion injury.
The myocardial damage from IRI is due in
The myocardial damage from IRI is due in