Mycophenolate Mofetil Research Paper

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MYCOCEPT (Mycophenolate mofetil) is the 2-morholinoethyl ester of mycophenolic acid (MPA).
CHEMICAL NAME: 2-morpholin-4-ylethyl (E)-6- (4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4 enoate.
STRUCTURAL FORMULA: Fig: Mycophenolate mofetil MOLECULAR WEIGHT: 433.50g/mol APPEARANCE: Mycophenolate mofetil, is a white to off-white crystalline powder. SOLUBILITY: It is slightly soluble in water (43µg/ml at pH 7.4); solubility increases in acidic medium (4.27mg/ml at pH 3.6); freely soluble in acetone; soluble in methanol; sparingly soluble in ethanol.
SHELF LIFE: For blisters is 12 months and for bottles is 24 months.
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2.3.8. INTERACTION WITH OTHER DRUGS: The interaction studies have been performed only in adults.
 ANTACIDS WITH ALUMINIUM AND MAGNESIUM HYDROXIDES There are decrease in absorption of mycophenolate mofetil was observed when administered in combination with antacids.
 ACYCLOVIR when mycophenolate mofetil was administered in combination with acyclovir, there is higher plasma concentrations of acyclovir were observed in comparison to alone administration of acyclovir.
 CYCLOSPORIN-A The pharmacokinetics of cyclosporine A (Cs A) are not affected by the co-administration of mycophenolate mofetil. In contrast, about 30% increase in MPA AUC should be expected in case the cyclosporine treatment is

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