CHEMICAL NAME: 2-morpholin-4-ylethyl (E)-6- (4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4 enoate.
STRUCTURAL FORMULA: Fig: Mycophenolate mofetil MOLECULAR WEIGHT: 433.50g/mol APPEARANCE: Mycophenolate mofetil, is a white to off-white crystalline powder. SOLUBILITY: It is slightly soluble in water (43µg/ml at pH 7.4); solubility increases in acidic medium (4.27mg/ml at pH 3.6); freely soluble in acetone; soluble in methanol; sparingly soluble in ethanol.
SHELF LIFE: For blisters is 12 months and for bottles is 24 months. …show more content…
2.3.8. INTERACTION WITH OTHER DRUGS: The interaction studies have been performed only in adults.
ANTACIDS WITH ALUMINIUM AND MAGNESIUM HYDROXIDES There are decrease in absorption of mycophenolate mofetil was observed when administered in combination with antacids.
ACYCLOVIR when mycophenolate mofetil was administered in combination with acyclovir, there is higher plasma concentrations of acyclovir were observed in comparison to alone administration of acyclovir.
CYCLOSPORIN-A The pharmacokinetics of cyclosporine A (Cs A) are not affected by the co-administration of mycophenolate mofetil. In contrast, about 30% increase in MPA AUC should be expected in case the cyclosporine treatment is