MuSK consists of fourteen exons and is found on chromosome 4 in mice and on chromosome 9 in humans. The structure of MuSK is divided between the extracellular region, transmembrane domain (TM), juxtamembrane domain (JM) and a catalytic domain. The extracellular region includes four immunoglobulin-like domains (Ig) and between the two last one a cysteine-rich domain (C6) represented in Figure 6B. Then it follows the TM, which is located in the membrane of the muscle fiber, the JM and the tyrosine kinase catalytic domain.
MuSK is activated trough the large heparansulfate proteoglycan agrin, a motor neuron protein. But agrin does not directly bind to the receptor tyrosine kinase MuSK, MuSK’s coreceptor Lrp4 binds first to agrin and this complex
MuSK is activated trough the large heparansulfate proteoglycan agrin, a motor neuron protein. But agrin does not directly bind to the receptor tyrosine kinase MuSK, MuSK’s coreceptor Lrp4 binds first to agrin and this complex