Sydney Elbert The first account of Muscular Dystrophy was in 1830. Sir Charles bell wrote an essay about a disease that caused weakness in boys. Six years later another scientist found two other boys that developed weakness, muscle damage, and damaged muscle tissue that was replaced with fat and connective tissue. 1850 more and more were reported in medical journals of having lost ability to walk, weakness, and death at an early age. Later on French neurologist Guillaume Duchenne found thirteen more boys with the most common and severe form of muscular dystrophy, Duchenne muscle dystrophy. Years later after more research they found out there was more than one form of muscular dystrophy that affected people of both sexes and of all ages. All
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The cells in the body don’t work correctly when a protein is altered or produced in not enough quantity, or sometimes not produced at all. Sometimes muscular dystrophies are caused by spontaneous mutations that can’t be found in their parents, the defect can be passed down to the next generation. There are three way muscular dystrophies can be inherited. One way being autosomal dominant inheritance which happens when the child receives one normal gene from a parent and one defective gene from another parent, only one parent is needed to pass along the abnormal gene in order to produce the disorder. When one parent has the abnormal gene there is a 50% chance that either gender can be at risk, depending on the person the disease is more or less severe. Another way is autosomal recessive inheritance which occurs when both parents have to carry and pass on the gene. Which means both of the parents have one defective gene but are not affected by it. Kids have a 25% chance of inheriting both copies of the defective gene and a 50% chance of inheriting one gene, which makes them a carrier, meaning they can pass it down to their children. The third way is x-linked recessive inheritance which means the mom has the affected gene on one of the two X chromosomes and passes
The cells in the body don’t work correctly when a protein is altered or produced in not enough quantity, or sometimes not produced at all. Sometimes muscular dystrophies are caused by spontaneous mutations that can’t be found in their parents, the defect can be passed down to the next generation. There are three way muscular dystrophies can be inherited. One way being autosomal dominant inheritance which happens when the child receives one normal gene from a parent and one defective gene from another parent, only one parent is needed to pass along the abnormal gene in order to produce the disorder. When one parent has the abnormal gene there is a 50% chance that either gender can be at risk, depending on the person the disease is more or less severe. Another way is autosomal recessive inheritance which occurs when both parents have to carry and pass on the gene. Which means both of the parents have one defective gene but are not affected by it. Kids have a 25% chance of inheriting both copies of the defective gene and a 50% chance of inheriting one gene, which makes them a carrier, meaning they can pass it down to their children. The third way is x-linked recessive inheritance which means the mom has the affected gene on one of the two X chromosomes and passes