Skeletal muscle is a highly specialized, post-mitotic tissue that must withstand chronic mechanical and physiological stress throughout life to maintain proper contractile function. Muscle damage or disease leads to progressive weakness and disability, and manifests in more than 100 different human disorders, including DMD, the most common X-linked genetic disorder in humans, and BMD. Current treatment options for muscular dystrophies are disappointingly limited and focus mainly on managing symptoms and suppressing the immune and inflammatory response. Because many dystrophies arise from inherited mutations in genes necessary for maintaining proper myofiber structure, repair potential or contractile function, therapeutic approaches that seek
