ABSTRACT: Muscle hypertrophy refers to increase in muscular size caused by expansion or
increasing count of myofibrils (hyperplasia) within skeletal muscles. Resistance-based training
causes microtrauma within myocytes of target muscles. Damage to muscle cells induce activation
of myosatellite cells, which proliferate as myoblast [1]. Myoblasts differentiate and recover
damaged cells as they fuse with the tissues, making the cell more durable than the original state.
Satellite cells may also fuse with one another to develop a new muscle [2] which results in
hyperplasia. Supplements such as; protein, BCAA, and HMB target supplying nutrients necessary
for the recovery phase as well as they stimulate mTOR/PI3K/Akt signaling pathways [3]. Creatine …show more content…
However, creatine itself does not have
direct anabolic effect in muscular hypertrophy [4]. Though, a few clinical studies recorded slight
inhibition of growth differentiation factor-8 (myostatin) [5]. Pre-workout supplements are used to
enhance resistance-training performance and generally contain: caffeine, β-alanine and l-arginine
as main ingredients [6]. Testosterone, androgen, and insulin-like growth factor (IGF-1)
increasing count of myofibrils (hyperplasia) within skeletal muscles. Resistance-based training
causes microtrauma within myocytes of target muscles. Damage to muscle cells induce activation
of myosatellite cells, which proliferate as myoblast [1]. Myoblasts differentiate and recover
damaged cells as they fuse with the tissues, making the cell more durable than the original state.
Satellite cells may also fuse with one another to develop a new muscle [2] which results in
hyperplasia. Supplements such as; protein, BCAA, and HMB target supplying nutrients necessary
for the recovery phase as well as they stimulate mTOR/PI3K/Akt signaling pathways [3]. Creatine …show more content…
However, creatine itself does not have
direct anabolic effect in muscular hypertrophy [4]. Though, a few clinical studies recorded slight
inhibition of growth differentiation factor-8 (myostatin) [5]. Pre-workout supplements are used to
enhance resistance-training performance and generally contain: caffeine, β-alanine and l-arginine
as main ingredients [6]. Testosterone, androgen, and insulin-like growth factor (IGF-1)