Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. It is autoimmune, but is genetically influenced by the environment, such as the Epstein-Barr virus, Vitamin D deficiency, and smoking. However, In 1966, Leibowitz et al first suggested that MS might be associated with high sanitation standards during childhood, but, some studies since then over the so called hygiene hypothesis, that proposes that infections in childhood are protective against autoimmune diseases, have shown otherwise. This study broadly investigates the possible association between the occurrence of MS and environmental factors in early childhood by evaluating important details. A case-control study was carried out by 245 MS
