Mr Penzey Case Study

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1. What were the main findings of Mr. Penzey’s physical exam? How could his CT results be related to his blood pressure findings?
A physical examination for high blood pressure also comprises a medical history. The extent of the physical examination as well as the level of detail in your doctor's questions depend on how high your blood pressure is in addition to whether you have other risk factors for heart disease.
High blood pressure can harm your blood vessels, heart as well as kidneys. This damage can cause a heart attack, stroke or other health problems. Your blood pressure reading is based on two measurements so-called systolic (the top number) as well as diastolic (the bottom number) written as a ratio, for instance (120/80 mmHg). Generally if your blood pressure is more than 140/90 mmHg when measured in your
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What did the genetic results suggest about Mr. Penzey’s condition? The mutation on the agarose gel showed the presence of a chimeric 11-β-hyroxylase gene which caused an overproduction of the enzyme aldosterone synthase. How is this enzyme involved in the function of ACTH, aldosterone and cortisol? How do these hormones affect the homeostasis of blood pressure?
The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme is found in the adrenal glands, which are located on top of the kidneys. The 11-beta-hydroxylase enzyme is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation as well as breakdown of various molecules in cells.
The 11-beta-hydroxylase enzyme helps produce hormones so-called cortisol as well as corticosterone. Specifically, the enzyme helps convert a molecule so-called 11-deoxycortisol to cortisol, in addition to aids convert another molecule so-called 11-deoxycorticosterone to corticosterone. These processes are triggered by the release of a hormone so-called adrenocorticotropic hormone (ACTH) by the pituitary gland, located at the base of the

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