Mitosis is a part of the cell cycle in which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, and each set ends up in its own nucleus. Mitosis is composed of several different components: Interphase, Prophase, Metaphase, Anaphase, and Telophase. Interphase is the stage that happens right before mitosis, this is where a typical cell spends most of its life. In the prophase stage of mitosis, the first stage of cell division, the chromosomes become visible as paired chromatids and the nuclear envelope disappears. During the metaphase stage of mitosis, the eukaryotic cell cycle in which chromosomes are at their second-most condensed and coiled stage.
Anaphase, is the stage of mitosis when replicated chromosomes …show more content…
Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to an infant if given during pregnancy.
The spindles in mitosis are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. The drug vincristine disrupts the formation of the spindles and therefore interrupt cell division. The drugs that harm the process of mitosis are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. Vincristine irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. VCR was found to affect cells in interphase, producing a transient G2 block at all drug concentrations and drug exposure durations studied. VCR did not affect DNA synthesis directly. This drugs causes the mitosis cell cycle to stop during the metaphase
Anaphase, is the stage of mitosis when replicated chromosomes …show more content…
Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to an infant if given during pregnancy.
The spindles in mitosis are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. The drug vincristine disrupts the formation of the spindles and therefore interrupt cell division. The drugs that harm the process of mitosis are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. Vincristine irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. VCR was found to affect cells in interphase, producing a transient G2 block at all drug concentrations and drug exposure durations studied. VCR did not affect DNA synthesis directly. This drugs causes the mitosis cell cycle to stop during the metaphase