In couples with at least two miscarriages , there is a balanced chromosome rearrangement in one of a partners. The most common of these is a segment of nonhomologous chromosome has exchanged places with a segment of a normal chromosome .If there is a such a rearrangement , the chromosomes have difficulty to be paired up and divided normally during meiosis. The result of these is that an unbalanced amount of chromosomal material (deficiencies) possessed usually by gametes. These abnormal balances are usually fatal for the embryo that is developing or fetus causing as a result an miscarriage. Sometimes, if pregnancy continues with the above situation mentioned , the baby is born with significant congenital anomalies and mental
