Duloxetine 60mg once Daily in the Treatment of Milder Major Depressive Disorder
Elke Sandoval
California State University Long Beach
11/10/2015
11: 00 am -12: 15 pm Summary Selection
Introduction and hypothesis
The researchers for this study wanted to conduct this experiment due to the controversy in treating patients with mild major depressive disorder (MMDD) through anti depressants. They realized that there are many studies on the effectiveness of anti depressants on moderate and major depressive disorder but hardly any with MMDD. In this research paper they performed a study in which they treated patients who under DSM 5 meet criteria for major depressive disorder, but less severe. The anti depressant they used was duloxetine …show more content…
They understand that the negatives outweigh the positives. Such as the fact that patients with MMDD may suffer more on antidepressants, because of their intolerability. Another negative is that society uses the term “mild depression” to describe different states of depression that are not intertwined. On the contrary major depressive disorder has a concrete definition and specific symptoms to diagnose this disorder easily. There are many forms of mild depression so when the term is mention people can think anything from persistent depressive disorder to subsyndromal depression. It is a form of depression but the durability of these episodes, impairment and symptoms vary in time and severity. Therefore, finding patients to participate in MMDD case studies may be difficult, or findings on MMDD can be …show more content…
It took place in thirty-nine centers all over the United States. The study included male and females who were at least eighteen years old. In order to qualify for the study they needed to meet criteria for major depressive disorder through DSM 5. Patients were excluded if they had an Axis I or II disorder, an anxiety disorder within a year of the study, and dysthymia. Along with substance abuse and medical illness.
What are the techniques or procedures they used to collect the data?
The primary tool to measure the effectiveness of this study was the Hamilton Depression Rating Scale (HAMD). Other forms of measurements were the Patient Global Impression-Improvement (PGI-I) scale, and the Somatic Symptom Inventory (SSI). The numeric results were measured through a post-hoc analysis and an analysis of covariance (ANCOVA) model. In the first trial eighty-four patients were given a placebo pill, and seventy-five were given 60mg of duloxetine. In the second trial eighty-two were given the placebo pill, and seventy-one patients were given 60mg of duloxetine. Both were taken on a daily basis.
Elke Sandoval
California State University Long Beach
11/10/2015
11: 00 am -12: 15 pm Summary Selection
Introduction and hypothesis
The researchers for this study wanted to conduct this experiment due to the controversy in treating patients with mild major depressive disorder (MMDD) through anti depressants. They realized that there are many studies on the effectiveness of anti depressants on moderate and major depressive disorder but hardly any with MMDD. In this research paper they performed a study in which they treated patients who under DSM 5 meet criteria for major depressive disorder, but less severe. The anti depressant they used was duloxetine …show more content…
They understand that the negatives outweigh the positives. Such as the fact that patients with MMDD may suffer more on antidepressants, because of their intolerability. Another negative is that society uses the term “mild depression” to describe different states of depression that are not intertwined. On the contrary major depressive disorder has a concrete definition and specific symptoms to diagnose this disorder easily. There are many forms of mild depression so when the term is mention people can think anything from persistent depressive disorder to subsyndromal depression. It is a form of depression but the durability of these episodes, impairment and symptoms vary in time and severity. Therefore, finding patients to participate in MMDD case studies may be difficult, or findings on MMDD can be …show more content…
It took place in thirty-nine centers all over the United States. The study included male and females who were at least eighteen years old. In order to qualify for the study they needed to meet criteria for major depressive disorder through DSM 5. Patients were excluded if they had an Axis I or II disorder, an anxiety disorder within a year of the study, and dysthymia. Along with substance abuse and medical illness.
What are the techniques or procedures they used to collect the data?
The primary tool to measure the effectiveness of this study was the Hamilton Depression Rating Scale (HAMD). Other forms of measurements were the Patient Global Impression-Improvement (PGI-I) scale, and the Somatic Symptom Inventory (SSI). The numeric results were measured through a post-hoc analysis and an analysis of covariance (ANCOVA) model. In the first trial eighty-four patients were given a placebo pill, and seventy-five were given 60mg of duloxetine. In the second trial eighty-two were given the placebo pill, and seventy-one patients were given 60mg of duloxetine. Both were taken on a daily basis.