The Indian subcontinent has served as a major corridor for the genetic diversity of its inhabitants. Modern-day human population dispersal routes is punctuated with delineating migrations that eventually led anatomically modern humans (AMH) to spread over most parts of the world within the past 100,000 years (Cavalli- Sforza, Menozzi and Piazza 1994; Lahr and Foley 1994). Migration waves are influenced by landscape traversed and thus, natural inter continental passageways acting as corridors played a key-role in the evolutionary history of human population migration events. Mitochondrial DNA polymorphism (mtDNA, Y chromosome markers (Cordaux et al., 2004), microsatellites (Belle and Barbujani 2007) and autosomal genes (Wang et al.,1998) are
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Due to their unique geographic position (flanked in the northern side by young fold mountains of Himalayas and the Bay of Bengal on the southern coast), leads to restricted external gene flow, these diverse populations retain a unique population structure which in turn is expected to mirror in their genome pools (Krithika et al. 2008). This region is distinguished by a preponderance of the Tibeto Burman migrants, and the inhabitants here is thought to comprise migrating peoples from East and Southeast Asia, who are presumed to have brought with them the risk for stomach cancer (Kataki et al., 2011). The prevalance of stomach cancer in India is lower, than that of any other country worldwide. However, the prevalence of stomach cancer was found to be in first position and fifth position globallyin Mizoram , one of the mountainous state nestling in the southern tip of north-eastern region of India compared to other parts of India (Phukan et al, 2004). Etiology of stomach cancer includes Helicobacter pylori infection, diet that includes pickled food, rice intake, spicy food, salted meat,lifestyle, tobacco, alcohol and genetic …show more content…
pylori strains isolated from individuals of both sexes (aged between 30-60years) who presented with gastrointestinal disorders underwent a non-sedated upper gastrointestinal endoscopy under topical lignocaine anesthesia at the Civil hospital Mizoram, India were included in this study. Patients who had received non-steroidal anti-inflammatory drugs, H2-receptor blockers, antibiotics, antihistamines prior to endoscopy were excluded from this study. During upper gastrointestinal endoscopy, biopsy samples were taken from the antrum and body of the stomach for rapid urease test (RUT), and culture. Biopsy sample in 0.6 ml of brucella broth (Difco Laboratories, Detroit, Mich.) containing 15% glycerol were transported to the Bacteriology Division of the National Institute of Cholera and Enteric Diseases under cool chain condition and stored at - 70°C until
Due to their unique geographic position (flanked in the northern side by young fold mountains of Himalayas and the Bay of Bengal on the southern coast), leads to restricted external gene flow, these diverse populations retain a unique population structure which in turn is expected to mirror in their genome pools (Krithika et al. 2008). This region is distinguished by a preponderance of the Tibeto Burman migrants, and the inhabitants here is thought to comprise migrating peoples from East and Southeast Asia, who are presumed to have brought with them the risk for stomach cancer (Kataki et al., 2011). The prevalance of stomach cancer in India is lower, than that of any other country worldwide. However, the prevalence of stomach cancer was found to be in first position and fifth position globallyin Mizoram , one of the mountainous state nestling in the southern tip of north-eastern region of India compared to other parts of India (Phukan et al, 2004). Etiology of stomach cancer includes Helicobacter pylori infection, diet that includes pickled food, rice intake, spicy food, salted meat,lifestyle, tobacco, alcohol and genetic …show more content…
pylori strains isolated from individuals of both sexes (aged between 30-60years) who presented with gastrointestinal disorders underwent a non-sedated upper gastrointestinal endoscopy under topical lignocaine anesthesia at the Civil hospital Mizoram, India were included in this study. Patients who had received non-steroidal anti-inflammatory drugs, H2-receptor blockers, antibiotics, antihistamines prior to endoscopy were excluded from this study. During upper gastrointestinal endoscopy, biopsy samples were taken from the antrum and body of the stomach for rapid urease test (RUT), and culture. Biopsy sample in 0.6 ml of brucella broth (Difco Laboratories, Detroit, Mich.) containing 15% glycerol were transported to the Bacteriology Division of the National Institute of Cholera and Enteric Diseases under cool chain condition and stored at - 70°C until