Microbial Control And Effects Of H. Pylori

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Register to read the introduction… pylori gene that is called cagA which uses a type IV secretion system (TFSS) - a structure similar to a hypodermic needle - to inject the CagA protein into epithelial cells of the stomach lining. These cells then release pro-inflammatory proteins called cytokines, which attract white blood cells that damage stomach tissue by dispersing highly reactive oxygen and nitrogen compounds. The effects of H. pylori depends on the interactions of the bacteria and its hosts. For example, strains with the cagA gene damage the stomach tissues severely, have a strong control on acidity levels causing prevention from esophageal diseases, and have microbial control than the people without the cagA gene in H. pylori. …show more content…
pylori strain, unlike cagA. VacA forms holes inside the epithelial cells and curbs the immune response by immobilizing another type of white blood cell. Later, John C. Atherton, found four major variations in vacA: m1, m2 in middle of gene and s1, s2 in the region that encodes the protein’s signal sequence, which enables the protein to move through cell membranes. Also it was determined that s1 could be divided into three subtypes: s1a, s1b, and s1c. From all these variations in vacA, m1 and s1 produce the most damaging toxin making these genotypes of vacA, combined with cagA to cause stomach cancer.
Research has also shown that variations in the H. pylori tend to cluster in certain geographic regions. Because of H. pylori being more genetically diverse than humans, it can elucidate the history of population movements better than DNA. Blaser states that the elimination of H. pylori with antibiotics tends to lower leptin which signals the brain to stop eating and increase ghrelin which simulates appetite causes increase in

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