As transdermal delivery is a non-invasive route for the therapeutic materials delivery from the intact skin towards the systemic circulation. And as every square centimeter of the surface of the human skin contains ≈10–70 hair follicles and ≈200–250 sweat glands, hence the skin surface could be a conduit for the delivery of therapeutic agents. Additional benefits of using transdermal route is being a painless delivery method, few side effects, providing a low-frequency of therapy administration, and avoidance of the first pass-effect in the liver. Moreover, the steady permeation of drugs/therapeutic materials transversing the skin allows constant levels of the delivered drug in plasma, so drugs can be maintained for a prolonged time in the
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In addition to antiproliferative activity, low dose MTX has antiinflammatory and immunomodulating properties, leading to its use in the treatment of different diseases, such as psoriasis, multiple sclerosis and rheumatoid arthritis. It is very similar structurally to the natural folates, and has a high binding affinity for the enzymes involved in DNA synthesis. The drug specifically inhibits competitively and reversibly dihydrofolato reductase. MTX is still serving as the gold standard therapy used to be prescribed systemically in psoriasis. The problem faced the topical forms of this drug was its solubility in the water and the ionized nature at the physiological pH mainly cause reduction in the passive diffusion through layers of the skin. Noticeably, psoriatic skin shows reduced water content and impaired barrier function, concludes to that water holding capacity and transepidermal water loss (TEWL) in psoriatic skin lesion is related to the severity of the disease and lesser topical hydrophilic drug absorption just like …show more content…
Testing the capability of the synthesized bioconjugate of hydrophilic gold nanoparticles (Au 3MPS) loaded MTX to apply topically by evaluating the efficacy on skin culture and imiquimod-induced psoriasis like mice model and testing the clinical response, epidermal thickness, cell proliferation after treatment with nanoparticle alone versus the
In addition to antiproliferative activity, low dose MTX has antiinflammatory and immunomodulating properties, leading to its use in the treatment of different diseases, such as psoriasis, multiple sclerosis and rheumatoid arthritis. It is very similar structurally to the natural folates, and has a high binding affinity for the enzymes involved in DNA synthesis. The drug specifically inhibits competitively and reversibly dihydrofolato reductase. MTX is still serving as the gold standard therapy used to be prescribed systemically in psoriasis. The problem faced the topical forms of this drug was its solubility in the water and the ionized nature at the physiological pH mainly cause reduction in the passive diffusion through layers of the skin. Noticeably, psoriatic skin shows reduced water content and impaired barrier function, concludes to that water holding capacity and transepidermal water loss (TEWL) in psoriatic skin lesion is related to the severity of the disease and lesser topical hydrophilic drug absorption just like …show more content…
Testing the capability of the synthesized bioconjugate of hydrophilic gold nanoparticles (Au 3MPS) loaded MTX to apply topically by evaluating the efficacy on skin culture and imiquimod-induced psoriasis like mice model and testing the clinical response, epidermal thickness, cell proliferation after treatment with nanoparticle alone versus the