Pathophysiology
In metabolic syndrome many organs are affected due to malnutrition, stress and inactivity. With all these factors playing a part the body has different ways of trying to protect it self, that in turn can cause more harm than good. Abdominal obesity, insulin resistant, hypertension, and chronic cortisol release are results of the factors which contribute to metabolic syndrome.
Abdominal Obesity
A high consumption of calorie dense food and lack of physical activity are contributes to obesity. Obesity is associated with high level of macrophages in adipose tissue and chronic low grade inflammation. Adipose tissue macrophages (ATMs) disrupt the function of adipocyte causing these cells to enlarge resulting in lack of blood supply. Macrophages and t cells are immune cells that infiltrate adipose tissue causing adipocytes to swell this in turn leads to insulin resistance. Beta cells from the pancreas then releases more insulin into the blood stream as if the amount of insulin already released was not sufficient. In obese cases inflammatory mediators are exaggerated after a meal especially if high in …show more content…
When a patient is obese visceral fat inflammation tampers with the signaling of the receptors on adipose cells impairing insulin absorption. Then more insulin is released into the blood causing elevated blood glucose or type 2 diabetes. Cells also start to die off due to lack of glucose breakdown for energy and nutrition. When insulin is not being absorbed by the cells it remains in the blood stream to be filtered by the liver. The liver will become damaged from filtering the over production of insulin and eventually cause chronic liver disease. Scar tissue will replace normal tissue impairing the liver from receiving proper blood supply. The liver will become prone to cancer or even
In metabolic syndrome many organs are affected due to malnutrition, stress and inactivity. With all these factors playing a part the body has different ways of trying to protect it self, that in turn can cause more harm than good. Abdominal obesity, insulin resistant, hypertension, and chronic cortisol release are results of the factors which contribute to metabolic syndrome.
Abdominal Obesity
A high consumption of calorie dense food and lack of physical activity are contributes to obesity. Obesity is associated with high level of macrophages in adipose tissue and chronic low grade inflammation. Adipose tissue macrophages (ATMs) disrupt the function of adipocyte causing these cells to enlarge resulting in lack of blood supply. Macrophages and t cells are immune cells that infiltrate adipose tissue causing adipocytes to swell this in turn leads to insulin resistance. Beta cells from the pancreas then releases more insulin into the blood stream as if the amount of insulin already released was not sufficient. In obese cases inflammatory mediators are exaggerated after a meal especially if high in …show more content…
When a patient is obese visceral fat inflammation tampers with the signaling of the receptors on adipose cells impairing insulin absorption. Then more insulin is released into the blood causing elevated blood glucose or type 2 diabetes. Cells also start to die off due to lack of glucose breakdown for energy and nutrition. When insulin is not being absorbed by the cells it remains in the blood stream to be filtered by the liver. The liver will become damaged from filtering the over production of insulin and eventually cause chronic liver disease. Scar tissue will replace normal tissue impairing the liver from receiving proper blood supply. The liver will become prone to cancer or even