I is a great tool for medical imaging and widely used for MS, but it has some limitations in lacking specificity and MRI not capturing diffuse white matter pathology 1. New emerging techniques such as transcranial magnetic stimulation (TMS) and optical coherence tomography (OCT) for monitoring visual impairment by MS have the potential to address issues not resolved by current MRI techniques. TMS is a new method not widely used yet, but suitable to detect the conditions affecting MS patients.
TMS is a painless and non-invasive technique providing a method to study the central nervous system (CNS) in a pain-tolerated manner. TMS focuses on studying the motor neuron (MN) system of the CNS. TMS works by attaching a wire coil to a scalp that transfers a high, but short current to create a magnetic field at right angles relative to wire coil2. Action potentials (AP) are fired as a response to the cortical MN being excited. AP travel along the corticospinal pathway and results are recorded as a motor evoked potential (MEP) at peripheral muscles2. …show more content…
However, there have been cases of some patients experiencing seizures and strokes, but these are few individual cases only. Causal links have yet to be proven in the case of seizures since they occurred after TMS treatment. (???)
TMS uses single-pulsed and pair-pulsed techniques to study the motor system. There are several parameters for TMS, but some of the most common are MEP, motor threshold (MT), and central motor conduction time (CMCT).
A supra-threshold stimulus is used to measure MEP, this stimulus is higher than one used for MT. The results of the stimulus records amplitude and latency from peak to peak. MEP also determines corticomotor neuron strength through the excitability of different neurons at different intensities of
TMS is a painless and non-invasive technique providing a method to study the central nervous system (CNS) in a pain-tolerated manner. TMS focuses on studying the motor neuron (MN) system of the CNS. TMS works by attaching a wire coil to a scalp that transfers a high, but short current to create a magnetic field at right angles relative to wire coil2. Action potentials (AP) are fired as a response to the cortical MN being excited. AP travel along the corticospinal pathway and results are recorded as a motor evoked potential (MEP) at peripheral muscles2. …show more content…
However, there have been cases of some patients experiencing seizures and strokes, but these are few individual cases only. Causal links have yet to be proven in the case of seizures since they occurred after TMS treatment. (???)
TMS uses single-pulsed and pair-pulsed techniques to study the motor system. There are several parameters for TMS, but some of the most common are MEP, motor threshold (MT), and central motor conduction time (CMCT).
A supra-threshold stimulus is used to measure MEP, this stimulus is higher than one used for MT. The results of the stimulus records amplitude and latency from peak to peak. MEP also determines corticomotor neuron strength through the excitability of different neurons at different intensities of