Mechanisms of nicotine are very complicated due to several factors. One of the most important things that nicotine’s effect depends on is the dose as it effects Blood pressure , Irregular heartbeats , Hypothermia , Cognitive alternations , Analgesia and excitation . Nicotine is absorbed in several ways as in the wall of the small air sacs in lungs , through the mucous membranes of nose or mouth when sniffed or chewed and via the skin . Regardless of absorption, nicotine goes to blood stream to be distributed completely through blood-brain barrier . Acetylcholine is the neurotransmitter in which the nicotine molecule is shaped like, however unlike acetylcholine as nicotine causes chemical changes and addictions which disturbs normal brain functions.
