Mangiferin Essay

897 Words 4 Pages
Discussion
We have carefully evaluated anti-inflammatory and anti-arthritic activity of Mangiferin (NF-κB inhibitor) and its interactions with low dose of NO modulators (L-NAME and L-Arginine) for the treatment of adjuvant-induced experimental arthritis in rats.
Maximum anti-inflammatory and anti-arthritic activity of Mangiferin was observed in rats treated with Mangiferin 30 mg/kg. Its protective effect was potentiated by combination with low dose of NO modulator L-NAME (10 mg/kg). Treatment with Mangiferin has improved general quality of life of CFA inoculated rats and has prevented and restored the loss in body weight.
Increase in ROS/RNOS activity in CFA inoculated rats, results in significant increase in MDA levels; while SOD activity is markedly suppressed. Mangiferin due to its ROS/RNOS inhibiting property decreases MDA levels, while SOD activity is restored significantly. Mangiferin regulates oxidative stress by (1) modulating Nrf2/antioxidant response element (ARE) detoxification pathway; (2) directly detoxifying reactive species such as ROS and RNS; (3) activating detoxification enzymes such as catalase. In addition, Mangiferin inhibits
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Findings, of this study are in agreement with earlier studies which have reported role of NO in inflammatory/auto-immune disorders. Our study, provides the evidence that inhibition of NO production is one of the factor involved in the anti-inflammatory and anti- arthritic effects of Mangiferin. Anti-arthritic and anti- inflammatory effect of Mangiferin was further potentiated by its combination with low dose of NO modulator L-NAME. L-NAME when given in low dose exerts its anti- inflammatory effect by inhibiting NO-NOS pathway which promotes inflammation by activating various inflammatory mediators such as cyclooxygenase (Jarazo Dietrich et al.

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