Malaria And Hemoglobin Adaptation : A Type Of Normal Adult Hemoglobin

1417 Words Sep 20th, 2015 null Page
Over the generations, ancestors evolved different allele frequencies due to recurring natural selection. In fact, natural selection and mutation were considered the main hypotheses for the sickle gene cell. However, those hypotheses limit in explaining the entirety for the frequency of the HbS allele in human populations around the globe. The complex relationship between the HbS allele frequencies and the level of malaria prevalence support the malaria hypothesis at a global scale and further demonstrate why adaptation or natural selection alone cannot be the factor in explaining allele frequencies. According to Piel et. al. (2010), HbS, known as the sickle hemoglobin, is “a structural variant of normal adult hemoglobin” (p. 2). Piet et al. (2010) recognized several limitations from the past studies such as “biased HbS allele frequency estimates and population samples” (p.2). Before going into the comprehensive geographical maps and data, they presented how human populations showed responses to malaria based on multiple genetic factors. Malaria and hemoglobin adaptation seems to be an important relationship in explaining genetic disorders such as beta thalassemia and the sickle cell disease, which is caused by mutations in the HBB gene (Genetics Home Reference: HBB, 2015). A single mutation on the Hb gene not only produces sickle blood cells but also impairs hemoglobin functionality. Furthermore, A homozygote, which is when you inherit the disease allele from both parents,…

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