An example of peripety in Shakespeare's play is the contrast between Lady Macbeth and Macbeth. In the beginning, Macbeth was so upset when he killed Duncan. He talked about the blood on his hands, and how even Posiedon's water couldn't clean them. Lady Macbeth says its no big deal and some soap and water will do. Later, Lady Macbeth spazzes out when she realizes all the murders that have been done. It is one of her famous lines,
Out, damned spot! out, I say!—One: two: why,
Out, damned spot! out, I say!—One: two: why,