M. Paratuberculosis Strain Case Study

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The proteome of M. paratuberculosis strain JTC303 CF was different from that of the CE. Specifically, CF proteins generally had lower pIs (4.4 to 5.5) and smaller masses (most s immune system loses control of the pathogen, or the pathogen begins active replication, the organism disseminates, and the host response shifts to a Th2 type immune reaction. The hallmark of this infection stage is production of detectable serum antibodies. A positive relationship has been shown between the level of serum antibody production and the number of M. paratuberculosis isolated from fecal samples (8, 27).

A second possible explanation for the diversity in antibody-antigen binding patterns is host response variability to the infection. Paratuberculosis has

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