I agree with the statement, we can’t believe 100% to someone even to our best friends. There is an old latinese philosophy that says “Homo Homini Lupus” which means a man is a wolf to another man. This philosophy is an image of human nature. The wolf as a creature is thought, in this example, to have qualities of being predatory and cruel.…
• Inflammation of various tissues of the body (systemic lupus erythematosus). • Fabry disease. • Whipple disease. SYMPTOMS Symptoms of…
Lebo et al. (2000) stated that “Both purported parents were tested, and neither carries the gene deletion. Polymorphic simple-sequence repeat analyses at 15 loci on chromosome 1 and at 16 loci on other chromosomes confirmed parentage and revealed that a de novo mutation prior to maternal meiosis I, followed by nondisjunction in maternal meiosis II, resulted in an oocyte with two copies of the de novo (an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell) mutant allele.” Therefore during the fertilization by a sperm that did not carry a paternal chromosome 1, the child inherited two mutant MSUD2 alleles on two maternal number 1 chromosomes instead. If both parents carry the MSUD gene, each of their children has a 1 in 4 chance of getting the disorder, and a 1 in 2 chance of being a…
Neonatal lupus erythematosus is an uncommon autoimmune disease which associated with the transplacental passage of maternal autoantibodies which affect atrioventricular node and hiss bundles of fetus heart and can cause fibrosis and calcification of cardiac structure(3). Fetal exposure to these maternal autoantibodies can also because myocarditis creates a late onset cardiomyopathy (8). Our patient suffered from isolated CCHB without any evidence of structural damage or myocarditis. Almost CCHB can be defined at 18-28 weeks gestational age, 6 weeks after passage of maternal IgG autoantibodies, due to fetal bradycardia and its confirmation is by using fetal echocardiography. Our baby showed bradycardia at 29 gestational ages in routine sonography…
Abstract Lupus is a chronic autoimmune disease in which the human immune system is overactive. Chronic means that the signs and symptoms tend to last longer than six weeks and can last up to several years (Lupus Foundation of America, 2014). Autoimmune means the immune system cannot tell the difference between foreign invaders and healthy tissues within the body. Therefore, the body attacks itself by creating auto-antibodies that destroy the remaining healthy tissue (Lupus Foundation of America, 2014).…
However they still stress that unless your Lupus is dormant you should stay away from all vaccines. For example Dr. Abu-Shakra states, “Although vaccines are safe clinically, a transient increase of the titers of a wide range of autoantibodies may occur after vaccination.” (Mahmoud Abu-Shakra, 2009) This could be very dangerous to those with the disease Lupus because their immune systems are compromised. While SLE is a disease of the integumentary system it is also an autoimmune disease.…
Multiple Sclerosis (MS) is a disease that impacts the brain and spinal cord (central nervous system). MS impacts the brain and spinal cord because the myelin sheath, which protects nerve fibers, is attacked by the immune system. Nerve fibers over time deteriorate or they become severely damages to the point where it is not reversible. The cause of this disease is not yet known but is classified as an autoimmune disease. It is said that a mix between genetics and environmental factors could be responsible cause of multiple sclerosis.…
Although lupus affects people of all ages, it's most often diagnosed between the ages of 15 and 45. Lupus is more common in African-Americans, Hispanics and Asian-Americans. Some complications that can be faced when you have lupus, Lupus can cause serious kidney damage, and kidney failure is one of the leading causes of death among people with lupus. If your brain is affected by lupus, you may experience headaches, dizziness, behavior changes, vision problems, and even strokes or seizures.…
With the same symptoms accuring for males and females . Symptoms include extreme fatigue,headaches, painful and swollen joints, Fever,low blood volume known as,Swelling,Pain in the chest, butterfly shaped rash across the cheeks ,sensitive to lights,hair loss,abnormal blood clotting,mouth and nose ulcers. Nothing is for sure to cause Lupus but many scientist and doctors believe that Lupus develops in response to a combination of factors inside and outside the body. Factors including hormones,genetics,and environmental factors. Although there is no official cure, there is many treatments to help with Lupus symptoms.…
Lupus is a type of inflammatory disease that affects the immune system which causes your body to attack its own tissues and this disease is a very chronic disease with ongoing signs. There are proteins in your body called antibodies that can protect your body from different types of invaders like the flu. Your body can tell the difference between good and bad antibodies. Lupus is able to destroy a variety of cells and organs such as, joints, skin, liver, heart, and kidneys.…
Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects over 250,000 people in the United States alone. 90% of the patients with SLE are female, which indicates that there is either an important role in female hormones or a protective role in male hormones. However, it is also possible that the gene is carried on the X chromosome, making males less likely to contract the disease (Rahman, et al. 929). Autoantibodies are generated in people with SLE, meaning that the humoral immunity system has lost the ability to differentiate between foreign and native self. The most common autoantibody, anti-dsDNA, binds to double-stranded DNA in the cells and tissues; however, there are also anti-nucleosome, anti-Rho, anti-NMDA, and other…
In the association of the variation of ieTILs, HLA class I, and MICA expression numbers did not follow a trend, but were standardized after a median had been…
Hereditary diseases are controlled by two genes, one acquired from the…
Mok & Lau (2003) explain the pathophysiology as Defective immune regulatory mechanisms, such as the clearance of apoptotic cells and immune complexes, are important contributors to the development of SLE. The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and the shifting of T helper 1 (Th1) to Th2 immune responses leads to B cell hyperactivity and the production of pathogenic autoantibodies. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations.…
While experiencing the different vulnerabilities that real people are challenged with my life drastically changed during my senior year of high school. “Lupus”. This diagnosis took me on a path that never could be imagined. Being an average student and a dance team captain with the ability to think clearly and rapidly move all limbs then barely being able to walk down a flight of stairs was beyond the worst thing that could ever be experience during the happiest time of my life. After several years of trying to understand my condition, being in severe pain, overweight and depressed passion me into going into the healthcare field to not only control “lupus” but make a difference in the community.…