Lung Cancer Case Study

Great Essays
Lung Cancer is the leading cause to cancer-related deaths around the world, with approximately 1/3 of all cancer related death. (Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer)Approximately seventy percent of people who are diagnosed with lung cancer present with advanced or metastatic (Molina, Yang, Cassivi, Schild, & Adjei, 2008). Non-small-cell lung cancer accounts for approximately eighty-five percent of lung cancers diagnosed in the world. (Molina, Yang, Cassivi, Schild, & Adjei, 2008). There are many different types of treatment for non-small-cell lung cancer, but there has not been one specific treatment that has completely cured lung cancer. Three different types of treatments of non-small-cell lung …show more content…
(2005) conducted a phase three trial of the effectiveness of Erlotinib and chemotherapy in NSCLC. They wanted to determine if erlotinib can improve the outcome of patients with NSCLC. The trial consisted of 1,079 patients, where 539 were assigned to receive oral doses of erlotinib, while 540 were assigned to receive chemotherapy, followed by a placebo. People were chosen at random on the basis of tumor measurement. Between July 18, 2001 and August 19, 2002, the starting dose assigned to the 539 people on erlotinib was 150 mg. The median survival was 10.6 months in the erlotinib arm compared to 10.5 months in the placebo arm. When the researchers looked at race, age, sex and cancer stage there was no significant survival difference. When they looked at those who smoked versus those who did not smoke, those who had never smoked in the placebo arm had a 22.5 month survival on the erlotinib arm compared to the 10.1 month survival of those who have smoked. In the erlotinib arm, those who had smoke had an 8.4 month survival compared to the placebo arm’s 9.1 month survival. At the end of the trial, a total of 408 people on the erlotinib arm had survived compared to 453 people in the placebo arm after four months. In this article, erlotinib had a longer survival, but at the end of the first four months, more people had died from erlotinib then the placebo. At the end of six months, erlotinib continued to have more …show more content…
Al (2010) conducted a phase III study on erlotinib for people whose cancer did not progress after four cycles of chemotherapy. Platinum-based chemotherapy had a median survival of 8.11 months. Seventy to eighty percent of the people who received first-line chemotherapy had progression of cancer, but when the length of the chemotherapy trials was prolonged, there was no change. The researchers wanted to show that erlotinib with continuous chemotherapy afterwards showed an increase in response duration. The SATURN study included those who those with four cycles of platinum-based chemotherapy without progression in disease, and a negative pregnancy test were assigned either oral erlotinib (150 mg) or a placebo of chemotherapy until the progression of disease or death. Between December 2005 and May 2008, 1949 people were screened and received the first line of platinum-based chemotherapy. After the chemotherapy, 428 patients (22%) had shown disease progression, 162 (8%) had died and 89 (5%) withdrew consent. 381 patients (20%) were ineligible due to deteoriation greater than 1or no tumor samples were available (37 people). A total of 889 people were able to go forth and be assigned erlotinib (437 people) and placebo of chemotherapy (447 people). PFS was discovered to longer in the erlotinib arm than the placebo arm. At the end of the first six months, 83 people who had received erlotinib versus fifty three

Related Documents

  • Improved Essays

    Subjects participated in a 12-week, double blind, randomized placebo-controlled study and were followed every 4 weeks for three months to assess clinical and laboratory findings such as ESR, CRP, consumption of analgesic drugs, and duration of morning stiffness and pain. It was found that there was a decrease in morning stiffness in the omega-3 group from 128 minutes to 40 minutes. In addition, the average tender joints were reduced from 21 to 5 joints and the number of swollen joints dropped from 10 to 3. The average ESR in the omega-3 group decreased from 39 to 16 and there was a significant reduction in pain for the overall assessment of the disease. When compared to the control group, there was a decrease in the use of analgesic drugs in the omega-3 group…

    • 1122 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    Hematemesis Case Study

    • 1588 Words
    • 7 Pages

    Postoperative follow up revealed 2 (5.4%) cases that developed gallstones in the first year after surgery that required cholecystectomy. In a study on open classical D.S by Abd El-Razik et al. (25) he reported 1 (2.5%) case who developed cholilithiasis that needed cholycystectomy. Bowel obstruction was not reported in our study during the follow up period. Bowel obstruction by internal herniation was reported in 8 ( 2%) patients by Hess and Hess (13) after open classical DS and 3 (2.8 %) patients by Luján et al.…

    • 1588 Words
    • 7 Pages
    Improved Essays
  • Superior Essays

    A randomized, double-blind study of eighteen patients with treatment-resistant bipolar depression, Diazgrenados et al. (2010) treated these patients with an IV infusion of ketamine or saline two separate days, two weeks apart. He found that within forty minutes of administration, depressive symptoms were significantly improved for ketamine compared to saline, and that these improvements lasted through the third day, but began to die down around day ten. This study suggest that the advantageous effects of ketamine were effective in these TRD patients, however the effect was not sustained over a significant amount of time, but was more significant than traditional…

    • 1073 Words
    • 4 Pages
    Superior Essays
  • Superior Essays

    Through numerous studies in the field of psychological-health study, as early as 1893, an association between depression and the cause of different types of cancers seem to be widely studied. Five studies based on the link between severe or chronic depression and the development of cancer are reviewed. In a study of the causation of cancer in chronic depressed elders, Chronically Depressed Mood and Cancer Risk in Older Persons, results show that there is a considerable correlation between chronic depression and the risk of cancer in persons of 65 years and older. Out of the 4825 persons from the Established Populations for Epidemiologic Studies of the Elderly studied, 146 persons (3% of the total study sample) are chronically depressed (depressed…

    • 1392 Words
    • 6 Pages
    Superior Essays
  • Superior Essays

    About 80% who go into remission will go within a month of induction therapy, but in some patients the disease will come back, and lowering the cure to 40%. Chronic lymphoid leukemia, people with it usually survive nine years, but some have survived as long as 35 years. In stage I or II, remission occurs in about 70% of people treated with chemo, but it always comes back at some point. Chronic myeloid leukemia, depending on the person’s age, the extent of the disease and the treatments used depends on the survival. 60% of people younger than 40 with mild symptoms survive three years after treatment if they have a bone transplant.…

    • 1859 Words
    • 8 Pages
    Superior Essays
  • Superior Essays

    Florastor Case Studies

    • 966 Words
    • 4 Pages

    There were 71 patients who were unable to complete the study because of death during or after, transfer to another hospital, or discontinuation of the antibiotic treatment. This left 204 patients, whose average age was now 78.4 years old, who completed the study and were analyzed for occurrence of diarrhea. Of those 204, 98 received the placebo and 106 received S. boulardii capsules. There was no statistical difference in the occurrence of ADD (P=0.71) since 13 in the placebo group (13.3%) and 16 in the S. boulardii group (15.1%) developed diarrhea. The odds ratio (OR) was 1.16 with a 95% confidence interval (CI) of 0.53-2.56.…

    • 966 Words
    • 4 Pages
    Superior Essays
  • Improved Essays

    However, chemotherapy remains the mainstay of treatment for this group of patients. And primary chemotherapy with or without consolidating CRT is the current treatment choice in the UK.1 (Chauffert et al 2008); randomised patient with a diagnosis of LAPC between upfront CRT with a dose of 60 Gy in 30 fractions delivered concurrently with cisplatin and 5FU followed by maintenance gemcitabine and the second arm were treated with gemcitabine alone. the median survival was shorter in the CRT arm 8.4 months comparing to gemcitabine arm with median survival of 14.3 months. The author concluded that CRT followed by gemcitabine was more toxic and less effective comparing to chemotherapy alone and this clearly shows the important of chemotherapy.3 In LAPC there is high risk of micrometastaic disease and disease progression occurs in 30-40%of patients within the first 3-4 months, therefore initiating chemotherapy is the preferred treatment over upfront…

    • 829 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    From 2011 to 2013, approximately 39.0 percent of men and women will be diagnosed with cancer of any site at some point during their life. Death rates are higher for those who are middle age or older. The Hospital has a cancer center that specializes in care of these patients, doctors, nurses, nurse practitioners, and physician assistants all work together on this floor to achieve the best outcome of the patient. No two patients are alike, so treatment and the responses to treatment can vary between person to person. The most common cancer in females is Breast Cancer, with an average of 246,660 cases in 2016 and 40,450 deaths.…

    • 806 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Stephan Doering, Professor of Psychiatry at the University of Munster in Germany, and some of his colleagues. The study had 104 participants, all of which were women between the ages of 18 and 45, who had been diagnosed with borderline personality disorder. The study was supposed to take place for one year, however, only 49 of the 104 participants completed the entire year of therapy. Even though not all of the participants finished the entire course of treatment, 42 percent of the participants no longer met the criteria for BPD after the completion of the treatment. In addition to no longer meeting the diagnosis requirements for BPD, the participants also showed a decrease in suicidal behavior and actions, and an improvement in their interpersonal relationships at work (Hoermann,…

    • 1057 Words
    • 5 Pages
    Improved Essays
  • Superior Essays

    “Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors. Among 10 year survivors diagnosed with testicular cancer at age 35 years old, the risk of developing a second solid tumor was increased. Risk remained statistically significantly elevated for 35 years. We observed statistically significantly elevated risk for the first time for cancers of the pleura. Overall patterns were similar for seminoma and nonseminoma patients, with lower risk observed for nonseminoma patients treats after 1975.…

    • 1221 Words
    • 5 Pages
    Superior Essays

Related Topics