Levodopa Case Study Of L-Dopa

2614 Words 11 Pages
Register to read the introduction… Dopamine itself cannot be directly administered because it is unable to cross the blood-brain barrier. Levodopa is taken up by the brain, engulfed by cell processes in the striatum whose cell bodies lie in the substantia nigra, converted to dopamine, and released as the neurotransmitter. It is thought that levodopa is effective, even though it must undergo the last step in synthesis, because it allows the cell to skip the rate limiting step in dopamine synthesis catalyzed by tyrosine hydroxylase (Kandel, 655). This allows the remaining cells in the substantia nigra to work more efficiently in compensation for the huge cell death …show more content…
In the next few years it will be important for more investigation to be initiated into the etiology and treatment of the disease, because the older population of this country deserves to be to independent as long as possible and to remain a contributing part of society.


Adams, Raymond D., and M. Victor. Principles of Neurology. 4th ed. McGraw-HIll Information Services Co. New York: 1989.

Chan-Palay, V. "Depression and Dementia in Parkinson’s Disease: Catecholamine Changes in the Locus Coeruleus - Basis for Therapy."Dementia. Vol. 2. 1991., Pp. 7-17.

Fitzgerald, M. J. T. Neuroanatomy, Basic and Applied. Bailliere Tindall. London: 1985.

Kandel, E. R., J. H. Schwarz, and T. M. Jessel. Principles of Neural Science. 3rd ed. Elsevier. New York: 1991.

Korczyn, A. D. "Autonomic Nervous System Disturbances in Parkinson’s Disease." Advances in Neurology. Vol. 53, 1990, Pp., 463-468.

Langston, J. W. "Current Theories on the Cause of Parkinson’s Disease. " Journal of Neurology, Neurosurgery, and Psychiatry. 1989, suppl. ,pp. 13-i7.

Lees, AJ. "The On-Off Phenomenon." Journal of Neurology, Neurosurgery, and Psychiatry. 1989, suppl. ,pp.

Related Documents