Leu Neururological Damage Associated With MSUD Case Study

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Register to read the introduction… A group of scientists in South America decided to further investigate this occurrence using 30-day-old male Wistar rats. Previous background revealed that leu provokes oxidative stress in rat brain homogenates by increasing the oxidation of lipids and by reducing the brain non-enzymatic antioxidant defense system. After incubating the rat cerebral cortex homogenates for an hour, various effects were observed when Leu was introduced to the equation. Leucine increased ThioBarbituric acid reactive substance levels, inhibited antioxidant enzyme activities and thiol in protein-SH content, and had little effect on the rate of DCFH oxidation and cyclic voltammeter studied. Results concluded that antioxidants such as vitamins E and C should be considered as a potential supplemental therapy for MSUD affected patients especially in predicaments when the levels of the brain chained amino acids increase …show more content…
What I found most interesting were the new ideas for future studies formulated as a result and the fact that you always learn something from an experiment. Regardless of if it’s what not to do next time, the scientists still advanced in their field of study. For example, a lot of scientists suggested that classic and intermediate mice models along with norleucine were very effective in studying potential treatment and brain injury. Another fascinating thought was the fact that inbreeding is the cause for the influx of MSUD in certain populations. Norleucine, an isomer of leucine used in experimental studies of protein structure and function, was also proposed as potential treatment to prevent encephalopathy in children with MSUD during catabolic stress. I chose to study this disorder for the same reason scientists are still conducting research, little is still known about it. With a name like maple syrup urine disorder, how could you not want to figure out what the disorder entails?
References
1. Bridi, R., Latini, A., Braum, C., Zorzi, G., Wajner, M., Lisis, E.;(2005). Evaluation of the mechanisms involved in leucine-induced oxidative damage in cerebral cortex of young rats. Free radical research; Vol. 39 Issue 1, p71-79,

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