Lavandula stoechas L. is the main antiepileptic and anticonvulsive medication in Traditional Iranian Medicine. Pharmacological In vivo studies support the use of this plant in the treatment of epilepsy and convulsion (8, 19). Lavandula stoechas L. has been mainly used in the form of lavender syrup. In this paper, we prepared this ancient dosage form using the instruction mentioned in the greatest TIM pharmacopeia, Qarabadin Kabir. Some innovations were made to improve the efficacy, safety and acceptability of the dosage form. Additionally, physicochemical characteristics of L.stoechas and lavender syrup as well as organoleptic parameters and antimicrobial effectiveness testing (challenge test) of the syrup were performed.
The moisture content indicates the quality of the plant and also its efficacy. Excessive moisture content forms an ideal medium for the growth of different types of microorganisms, which subsequently reduce the efficacy and quality of the plant. The percentage of moisture content was found to be 4%±0.02, which is acceptable for the genus Lavandula.
The ash value of the plant is an important parameter to illustrate the quality as well as purity of herbal medicine. Total ash, acid insoluble ash, and water soluble ash of the …show more content…
Luteolin, the main flavonoid of this plant has been reported to exert an effective role in reducing the seizure frequency and a protective effect on peripheral organ injury in animal models of seizure(30). Vitexin, another flavonoid occurring in lavender, has shown anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ-aminobutyric acid type A(GABAA) receptor complex(31). It is also likely that the calcium channel blocking activity of the plant phenolics is responsible for its anticonvulsive effect
The moisture content indicates the quality of the plant and also its efficacy. Excessive moisture content forms an ideal medium for the growth of different types of microorganisms, which subsequently reduce the efficacy and quality of the plant. The percentage of moisture content was found to be 4%±0.02, which is acceptable for the genus Lavandula.
The ash value of the plant is an important parameter to illustrate the quality as well as purity of herbal medicine. Total ash, acid insoluble ash, and water soluble ash of the …show more content…
Luteolin, the main flavonoid of this plant has been reported to exert an effective role in reducing the seizure frequency and a protective effect on peripheral organ injury in animal models of seizure(30). Vitexin, another flavonoid occurring in lavender, has shown anticonvulsant effects in the brain, possibly through interaction at the benzodiazepine site of the γ-aminobutyric acid type A(GABAA) receptor complex(31). It is also likely that the calcium channel blocking activity of the plant phenolics is responsible for its anticonvulsive effect