I found two interesting articles on the drug Lamotrigine. Lamotrigine is an antiepileptic drug. During my reading, I found conflicting literature that extends a value in the narrow range for this drug and other literature that suggests it is not consistent with a narrow therapeutic index (Greenberg, Melloni, Wu, Gonzalez, & Ku, 2016). Greenberg, Melloni, Wu, Gonzalez, & Ku, 2016 states that the therapeutic index for Lamotrigine in not well established. Lamotrigine does not have a clear dose to response curve for therapeutic dosing or toxicity (Greenberg, Melloni, Wu, Gonzalez, & Ku, 2016). The literature suggests that providers use individualized dosing for patients prescribed Lamotrigine (Greenberg, Melloni, Wu, Gonzalez, & Ku, 2016).
