Krabbe’s disease is an autosomal recessive degenerative disease. It is most commonly found in infants, but can be detected in later stages of life. This gene is passed from both parents who are carriers. This disease is rare and also known as globoid cell leukodystrophy.
This disease is caused by a mutation on chromosome 14 the GALC gene. The CALC gene is responsible for the production of an enzyme called galactosylceramidase. When there is a deficiency in the galactosylceraidase it causes the destruction of the myelin of the nerve cells in the brain and nervous system. The myelin protects and insulates the nerve to send signals to different parts of the body.
This disease is caused by a mutation on chromosome 14 the GALC gene. The CALC gene is responsible for the production of an enzyme called galactosylceramidase. When there is a deficiency in the galactosylceraidase it causes the destruction of the myelin of the nerve cells in the brain and nervous system. The myelin protects and insulates the nerve to send signals to different parts of the body.