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Kanamycin-Rifampicin Combination Powder

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Spray-dried powder particles of hygroscopic kanamycin with hydrophobic surface enrichment of rifampicin were successfully produced using a co-solvent system of ethanol and water. The kanamycin-rifampicin combination powders were amorphous in nature and flake-shaped in morphology. The aerosolization efficiency of kanamycin-rifampicin combination powder (% FPF: > 77.6) was higher than kanamycin-only powder (% FPF: < 29.1). The improved aerosolization may be due to the hydrophobic surface enrichment and/or change in particle morphology, which may possibly reduce interparticulate interactions. The combination powder was stable at 15% and 53% RH and 25 ± 2 °C during one-month storage. The drug powders were found to be non-toxic to respiratory cell

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