Kaempferol is a natural polyphenol, secondary metabolite (flavonol), a type of flavonoid, found in a variety of plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol acts as an antioxidant by reducing oxidative stress. Many studies suggest that consuming kaempferol may reduce the risk of various cancers, and it is currently under consideration as a possible cancer treatment. Epidemiological studies have revealed Kaempferol as a natural polyphenol belonging to the group of flavonoids. Epidemiological studies have found a positive association between the consumption of foods containing Kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases.
Insilico anticancer study of Kaempferol The X-ray crystal structure of IR (PDB; 3ETA), IGF1R (PDB; 1K3A), EGFR (PDB; 1M17), VEGFR2 (PDB; 2OH4), CXCR2 (PDB; 4JL7), CXCR4 (PDB; 3OE6), CCR5 (PDB; 4MBS), AR (PDB; 2PIV), ER (PDB; 3ERT), γ-secretase (PDB; 4Y6K), PARP1 (PDB; 1UK1), Smoothened 7TM (PDB; 7QIM), and Wnt (PDB; 1JDH) retrieved from the protein data bank and prepared by using Maestro 9.6 application of protein preparation wizzards. Molecular docking studies was conducted using Maestro 9.6 …show more content…
In the experimental periodontitis groups, systemic kaempferol (10 mg/kg/2d) and saline were administered by oral gavage at two different periods (with and without the presence of dental biofilm) to all rats except for the ten non-medicated rats. Alveolar bone area, alveolar bone level, and attachment level were determined by histomorphometric analysis, and gingival tissue levels of MMP-1, MMP-8, and TIMP-2 were detected by biochemical
Insilico anticancer study of Kaempferol The X-ray crystal structure of IR (PDB; 3ETA), IGF1R (PDB; 1K3A), EGFR (PDB; 1M17), VEGFR2 (PDB; 2OH4), CXCR2 (PDB; 4JL7), CXCR4 (PDB; 3OE6), CCR5 (PDB; 4MBS), AR (PDB; 2PIV), ER (PDB; 3ERT), γ-secretase (PDB; 4Y6K), PARP1 (PDB; 1UK1), Smoothened 7TM (PDB; 7QIM), and Wnt (PDB; 1JDH) retrieved from the protein data bank and prepared by using Maestro 9.6 application of protein preparation wizzards. Molecular docking studies was conducted using Maestro 9.6 …show more content…
In the experimental periodontitis groups, systemic kaempferol (10 mg/kg/2d) and saline were administered by oral gavage at two different periods (with and without the presence of dental biofilm) to all rats except for the ten non-medicated rats. Alveolar bone area, alveolar bone level, and attachment level were determined by histomorphometric analysis, and gingival tissue levels of MMP-1, MMP-8, and TIMP-2 were detected by biochemical