JAK/STAT Signaling Summary

Superior Essays
Show More
Dr. Joseph Larkin III is an associate professor in the department of Microbiology and Cell Science at the University of Florida where he teaches Immunology. In addition to teaching, Dr. Larkin oversees multiple immunology research projects involving regulatory T cells and their involvement in autoimmune diseases including type one diabetes, lupus, rheumatoid arthritis, and most recently, uveitis. Dr. Larkin was born and raised in Savannah, Georgia. When asked about how he became interested in science, he recalled a specific memory from his childhood. As a young boy, Dr. Larkin loved to watch Saturday morning cartoons and would wake up very early to do so. One Saturday morning, when Dr. Larkin was about ten years old, he saw the St. Jude …show more content…
A JAK/STAT signaling pathway sends signals from outside the cell into the gene promoters found on DNA. The JAK/STAT signaling pathway is essential to the development of T-lymphocyte development. On the other hand, when the JAK/STAT is activated when it should not be, autoimmune diseases arise. SOCS proteins are responsible for regulating the duration and intensity of JAK/STAT signaling. In Dr. Larkin’s research, he has concluded that SOCS1-KIR is able to suppress uveitis in experimental autoimmune uveitis, the animal model of human uveitis. (He, Yu, Sun, Mahdi, Larkin, and Egwuagu …show more content…
Larkin is working on very important research here at the University of Florida. As for his project on SOCS1 proteins and uveitis, he plans to soon expand his research from mice to horses. Horses are of particular interest because up to about ten percent of all horses have some form of uveitis, and many must retire and are at risk for euthanasia due to severe vision loss. Horses are also a good steeping stone between the treatment of uveitis in mice and uveitis in humans. In the future, he hopes that this treatment will be able to be used for patients with severe uveitis due to autoimmunity in order to preserve and restore eyesight. In addition to his uveitis research, Dr. Larkin is also working on projects involving Type 1 Diabetes, Lupus, and Rheumatoid

Related Documents

  • Improved Essays

    Cd20 Unit 4
    • 601 Words
    • 3 Pages

    Cd20 Unit 4

    Homework 4 1. A. Hcd19Tg is Human CD-19-Transgenic mice overexpressing CD19 which is a B-lymphocyte antigen present on all B cells. It is a transgenic model of human gene CD-19 introduced into the mice for research studying the effect of CD19 related to B-cell related immunological response B. CD1dloCD5+ is a rare phenotype of Regulatory B cells found in spleen of normal and autoimmune mice producing IL-10 and hence also called the B10 cells. As this phenotype is identifies to regulate T cell dependent inflammatory response, they are researched for role in myasthenia gravis and other neuro inflammatory diseases. C. Terbutaline is a B2 adrenergic receptor agonist causing vasodilation, smooth muscle relaxation and skeletal muscle contractions.…

    • 601 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Psy 270 Week 2 Journal Analysis
    • 358 Words
    • 2 Pages

    Psy 270 Week 2 Journal Analysis

    This week I worked with Dr. Lanting, his scribe, Anna, and three other Medical Assistants. Their names are Juana who is the MA supervisor, Andre, and Annette. It seems like Monday’s and Tuesday’s are the busiest days at the clinic. It seems like the more time at the clinic the more I am learning. There are so many up and coming medications out there for chronic idiopathic uticaria and Asthma.…

    • 358 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Daniel Hale Williams Research Paper
    • 340 Words
    • 2 Pages

    Daniel Hale Williams Research Paper

    Open Hearts: The Work of Daniel Hale Williams Germs don’t discriminate, why should hospitals? Daniel Hale Williams, quite possibly the most prominent black physician of his time, sought to answer this question. Best known for performing the first successful recorded heart surgery, Williams spent his life working for the advancement of African-Americans within the medical field. Williams was born in 1856 in the town of Hollidaysburg, Pennsylvania.…

    • 340 Words
    • 2 Pages
    Improved Essays
    Read More
  • Great Essays

    Skin Cancer: Discussion Questions
    • 762 Words
    • 4 Pages

    Skin Cancer: Discussion Questions

    Part A Me Text Statement A A 1. If UV intensity levels doubled, mutations in animal cells, skin cancers, and cataracts would increase. “The intensity of UV radiation reaching the Earth’s surface doubled—levels that would increase DNA mutations in human and animal cells, suppress our immune systems, and increase the incidence of cataracts and skin cancer.”…

    • 762 Words
    • 4 Pages
    Great Essays
    Read More
  • Improved Essays

    George Herriman's Life And Accomplishments
    • 336 Words
    • 2 Pages

    George Herriman's Life And Accomplishments

    Have you ever heard of George Herriman? He was a famous cartoonist. What Is it he was famous for, you might ask. Well, he was famous for making the world wide loved comic strip Krazy Katz. It was a story about a cat named Krazy who had many adventures with his friends.…

    • 336 Words
    • 2 Pages
    Improved Essays
    Read More
  • Decent Essays

    Theodore Seuss Research Paper
    • 164 Words
    • 1 Pages

    Theodore Seuss Research Paper

    Theodore Seuss Geisel (Dr. Seuss) was born on March 2, 1904, in Springfield, Massachusetts. He was the only son of Henrietta Seuss Geisel and Theodore Robert Geisel. He had two sisters, Marnie, two years older and Henrietta 3 and a half years younger who died at the age of 5 because of pneumonia. At the time there was no cure and she eventually died. Theodore enjoyed reading comic strips, writing humorous poems, and drawing cartoons.…

    • 164 Words
    • 1 Pages
    Decent Essays
    Read More
  • Improved Essays

    Theodor Geisel's Oh, The Places He Went
    • 1786 Words
    • 8 Pages

    Theodor Geisel's Oh, The Places He Went

    Oh, The Places He Went Theodor Geisel wrote 44 different books in his lifetime. Although, you won’t see his name on any of them. Rather, you’ll see his pen name, Dr. Seuss. Many people know who Dr. Seuss is but not Theodor Geisel. They don’t know what Theodor Geisel was like as a person or what made him one of the most interesting writers in American history.…

    • 1786 Words
    • 8 Pages
    Improved Essays
    Read More
  • Improved Essays

    Il4 Vs Il-4
    • 439 Words
    • 2 Pages

    Il4 Vs Il-4

    4.1.5.Cytokine and Chemokine in inflammation: Many multifunctional cytokines are present in exocytosis of mast cells which play important roles in late- phase inflammatory response. The mast cell is a source of cytokines such as IL-1, -2, -4, -5, -6, TNF-α (85). IL-1 functions to grow T-helper cells and B cells with its proliferation whereas IL-2 influences the proliferation of T lymphocytes and activation of B lymphocytes. IL-4 helps to differentiate B lymphocytes into plasma cells secret IgE. With TNF-α, IL-4 regulates the expression of both high- and low-affinity IgE receptor on antigen presenting cells. IL-5 activates B lymphocytes and helps in the differentiation of eosinophils, and IL-6 causes B lymphocytes to increase the synthesis and…

    • 439 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Charles Epstein Accomplishments
    • 954 Words
    • 4 Pages

    Charles Epstein Accomplishments

    Charles J. Epstein was a highly regarded geneticist who made tremendous contributions to the medical field during his lifetime. He was born on September 3, 1933 in Philadelphia, Pennsylvania to Jacob C. Epstein and Frieda Epstein, Jewish immigrants from the Ukraine. During his high school years at Central High School, he excelled at academics and enjoyed track and field, and played the cello. After completing high school he went on to Harvard College where he graduated summa cum laude and received a chemistry degree. He married his girlfriend and fellow Harvard student, Lois Barth, despite being warned to wait until after they had both completed medical school.…

    • 954 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Muckle-Wells Syndrome
    • 1090 Words
    • 5 Pages

    Muckle-Wells Syndrome

    Muckle-Wells syndrome (MWS) is a rare genetic disorder that causes hive-like skin rashes, chills, fever, partial or total hearing loss, swollen joints, loss of kidney function, and can eventually lead to amyloidosis in some patients. Muckle-Wells syndrome is named after Thomas J. Muckle and Michael V. Wells who first described the disease in April of 1962 [1]. Muckle-Wells is in a family of diseases called Cryopyrin-Associated Autoinflammatory Syndromes (CAPS) which all are related because they are caused by a deficiency in the NLRP3 gene which is what codes for the protein Cryopyrin [2,3]. People tend to start showing symptoms as early as infancy or early childhood, and affects them for their entire lives, and if not treated can cause death…

    • 1090 Words
    • 5 Pages
    Improved Essays
    Read More
  • Superior Essays

    Marla Runyan Research Paper
    • 830 Words
    • 4 Pages

    Marla Runyan Research Paper

    Marla Runyan: A Visually Impaired Athlete Marla Runyan is a world-class track and field athlete, who competed for the United States Olympic Team in 2000. She also happens to have Stargardt’s disease, which makes her legally blind. Marla once said, “If I break a national record, maybe they will stop writing about my eyes” (LaFontaine 228).…

    • 830 Words
    • 4 Pages
    Superior Essays
    Read More
  • Improved Essays

    How Did Langston Hughes Influence The Harlem Renaissance?
    • 917 Words
    • 4 Pages

    How Did Langston Hughes Influence The Harlem Renaissance?

    A divided country. A battered race. A talented poet. Racism in the early to mid 1900s was obviously a major issue in the United States. Although it still is today, the differences in cultures caused races to be isolated from each other.…

    • 917 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Mr Ezzard Biography Essay
    • 557 Words
    • 3 Pages

    Mr Ezzard Biography Essay

    Ezzard If you had a chance to ask your teacher any questions, what would you ask them? Mr. Ezzard, the writing specialist at Biddeford Middle School, gave our class a chance to ask questions about his life. Mr. Ezzard has always enjoyed sharing his knowledge. He told us stories about the places he has been around the world, how he met his wife, Becky. He also told us about his interests and his unique job he had for the Peace Corp.…

    • 557 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Babe Ruth A Hero Essay
    • 997 Words
    • 4 Pages

    Babe Ruth A Hero Essay

    Social and cultural development is the progression of both the social and cultural ways of living of particular people and a country. People catalyze the growth in the society and in our case Babe Ruth, Charles Lindbergh, and Henry Ford participated in the cultural and economic development of their countries. In the 1920’s people spent most of their time partying rather than working and thus athletes were heroes as they were the only source of the people's entertainment. The Model T, sports heroes, and advancement in technology helped in the development of the social activities. Babe was a hero because of his skills in baseball sport, Charles Lindbergh was seen as a hero because of his non-stop solo flight across the Atlantic Ocean while Henry Ford is still admired today as a hero because he invented an affordable locomotive.…

    • 997 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    AMD Pathogenesis Essay
    • 295 Words
    • 2 Pages

    AMD Pathogenesis Essay

    Chronic inflammation is usually associated with accumulation of non-degradable substances, viral infection, and autoimmune disorders. In these situations, prolonged activation of immune cells can lead to tissue destruction, fibrosis, and uncontrolled angiogenesis. Despite the eyes are immune-privileged sites, deposition of inflammatory proteins in the drusen and observation of multiple types of immune cells in AMD eyes[9] indicate that this privilege is likely revoked. The immune-privileged of retina is achieved by formation of vascular barrier and secretion of immunosuppressive molecules[10]. RPE cells can modulate retinal immune response by secretion of immunosuppressive molecules PGE2 and PEDF to suppress T cell and macrophage activation, respectively [11, 12].…

    • 295 Words
    • 2 Pages
    Improved Essays
    Read More

Related Topics

Ready To Get Started?
Discover
Company
Follow
©2024 Cram.com
Privacy Policy |  About Ads |  Site Map |  Advertise  | 
  • Cookie Settings