Inhibition Peduncle Synthesis

motor cortex area to have decrease activity because of the increase inhibition from the

thalamus causing decrease activity to the lateral corticalspinal and rubrospinal tracts. The

result of this change is impairment of voluntary movement creating symptoms of such as

akinesia and bradykinesia. The next part of the motor loop to be affected is the increase

inhibition pedunculopontine nucleus causing disinhibition of the reticulospinal tract

causing rigidity of postural and girdle muscles. The last area of the motor circuit to be

affected is the increase inhibition in the midbrain locomotor area causing decrease signals

from the reticular formation to the spinal steeping pattern generators causing loss of

automatic gait.